oxaloacetate
Small moleculeexperimental
Oxaloacetic acid (also known as oxalacetic acid or OAA) is a crystalline organic compound with the chemical formula HO2CC(O)CH2CO2H. Oxaloacetic acid, in the form of its conjugate base oxaloacetate, is a metabolic intermediate in many processes that occur in animals. It takes part in gluconeogenesis, the urea cycle, the glyoxylate cycle, amino acid synthesis, fatty acid synthesis and the citric acid cycle. — Wikipedia
Clinical trial activity
11 trials · 9 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
2
Phase 3
1
Phase 4
0
Earliest trial started Dec 1, 2012 (NCT01741701)
Timeline
Indications
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
Loading structure…
SMILES
O=C(O)CC(=O)C(=O)O- Mol. weight
- 132.07 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaOxaloacetic acid ↗
- ChEMBLCHEMBL1794791 ↗
Also known as
- oxaloacetate
- oxaloacetate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05720624 | Phase 1 | Jan 30, 2024 | Mayo Clinic |
| NCT05273372 | N/A | Mar 15, 2022 | Bateman Horne Center, Terra Biological LLC |
| NCT04965987 | Phase 1 | Oct 31, 2021 | Terra Biological LLC, University of Kansas |
| NCT04450160 | Phase 2 | Dec 31, 2020 | MetVital, Inc. |
| NCT04592354 | N/A | Oct 15, 2020 | Terra Biological LLC |
| NCT04290897 | Phase 2 | Feb 29, 2020 | Breast Cancer Research Foundation, MetVital, Inc., University of California, Los Angeles |
| NCT04204889 | Phase 1 | Jan 31, 2020 | Rare Diseases Clinical Research Network, Terra Biological LLC, University of Kansas |
| NCT03509714 | N/A | Oct 17, 2016 | Energy Medicine research Institute, Terra Biological LLC |
| NCT02593318 | Phase 1 | Oct 1, 2015 | University of Kansas |
| NCT02063308 | N/A | Feb 1, 2014 | University of Kansas |
| NCT01741701 | Phase 2/Phase 3 (Phase 3) | Dec 1, 2012 | Terra Biological LLC, University of Kansas |
Showing 11 of 11 trials
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Organizations
Research & Development (9)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Terra Biological LLC | For profit | 6 | 3 | 3 | 2012 |
| University of Kansas | Academic/Hospital | 5 | 5 | 3 | 2012 |
| MetVital, Inc. | For profit | 2 | 1 | 1 | 2020 |
| Bateman Horne Center | Academic/Hospital | 1 | 0 | 1 | 2022 |
| Breast Cancer Research Foundation | Academic/Hospital | 1 | 0 | 1 | 2020 |
| Energy Medicine research Institute | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Mayo Clinic | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Rare Diseases Clinical Research Network | Academic/Hospital | 1 | 0 | 1 | 2020 |
| University of California, Los Angeles | Academic/Hospital | 1 | 1 | 1 | 2020 |
9 organizations
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