oleoylestrone
Small moleculeexperimental
Oleoyl-estrone (OE), or estrone 3-oleate, is a fatty acid ester of estrone. It is a naturally circulating hormone in animals, including humans. It was studied as a potential weight-loss drug, but failed to show benefit in clinical trials. It was first reported in 1996 to cause a body fat loss effect in rats in the International Journal of Obesity and Related Metabolic Disorders. The animal research has all been conducted by the Nitrogen-Obesity Research Group of the University of Barcelona. — Wikipedia
Clinical trial activity
3 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Jun 1, 2006 (NCT00449202)
Timeline
2000s
- Jan 1, 2006
Earliest Phase 2 Sponsor(trial)
Indications
Mechanism of action
- UnclearUnclear
Unclear unclear
Chemistry & pharmacology
Loading structure…
SMILES
CCCCCCCC/C=C\CCCCCCCC(=O)Oc1ccc2c(c1)CC[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12- Mol. weight
- 534.83 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaOleoyl-estrone ↗
- ChEMBLCHEMBL6067649 ↗
Also known as
- estrone 3-oleate
- estrone 3-oleate
- estrone monooleate
- estrone monooleate
- estrone oleic acid ester
- estrone oleic acid ester
- merlin-2
- mp-101
- mp-101
- oe
- oe
- oleoylestrone
- oleoylestrone
- oleoyl estrone
- oleoyl estrone
- oleoyl estrone
- oleoyl-estrone
- oleoyl-estrone
- oleoyl-estrone
- oleoyl-estrone
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03044249 | Phase 2 | May 4, 2017 | Mediti Pharma Inc. |
| NCT00449254 | Phase 2 | Oct 1, 2006 | Manhattan Pharmaceuticals |
| NCT00449202 | Phase 2 | Jun 1, 2006 | Manhattan Pharmaceuticals |
Showing 3 of 3 trials
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Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Manhattan Pharmaceuticals | For profit | 2 | 2 | 1 | 2006 |
| Mediti Pharma Inc. | For profit | 1 | 1 | 1 | 2017 |
2 organizations
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