nepicastat
Small moleculeexperimental
Nepicastat is an inhibitor of dopamine β-hydroxylase (DBH), an enzyme that catalyzes the conversion of dopamine to norepinephrine. — Wikipedia
Clinical trial activity
5 trials · 8 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started Jun 1, 2008 (NCT00656357)
Timeline
Indications
Mechanism of action
- Dopamine beta-hydroxylaseINHIBITOR
DBH inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
NCc1c[nH]c(=S)n1[C@H]1CCc2c(F)cc(F)cc2C1- Mol. weight
- 295.36 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaNepicastat ↗
- ChEMBLCHEMBL1188395 ↗
Also known as
- 5-aminomethyl-1-(5,7-difluoro-1,2,3,4-tetrahydronaphth-2-yl)-1,3-dihydroimidazole-2-thione
- nepicastat
- nepicastat
- nepicastat
- nepicastat
- rs 25560-197
- rs-25560-197
- syn117
- syn117
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05743010 | Phase 1 | Jan 26, 2023 | Jiangsu Asieris Pharmaceutical Technology Co., Ltd. |
| NCT01704196 | Phase 2 | Apr 1, 2013 | National Institute on Drug Abuse (NIDA) |
| NCT00659230 | Phase 2 | Jul 1, 2009 | Baylor University, Biotie Therapies, Department of Veteran Affairs, Tuscaloosa Research & Education Advancement Corporation (TREAC) |
| NCT00641511 | Phase 2 | Jun 1, 2008 | Baylor University, Biotie Therapies, Department of Veteran Affairs |
| NCT00656357 | Phase 1/Phase 2 (Phase 2) | Jun 1, 2008 | Biotie Therapies, National Institute on Drug Abuse (NIDA), The University of Texas, Dallas, University of Texas, Galveston |
Showing 5 of 5 trials
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Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Biotie Therapies | For profit | 3 | 1 | 1 | 2008 |
| Baylor University | Academic/Hospital | 2 | 0 | 1 | 2008 |
| Department of Veteran Affairs | Government | 2 | 1 | 1 | 2008 |
| National Institute on Drug Abuse (NIDA) | Government | 2 | 1 | 1 | 2008 |
| Jiangsu Asieris Pharmaceutical Technology Co., Ltd. | For profit | 1 | 1 | 1 | 2023 |
| The University of Texas, Dallas | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Tuscaloosa Research & Education Advancement Corporation (TREAC) | Academic/Hospital | 1 | 1 | 1 | 2009 |
| University of Texas, Galveston | Academic/Hospital | 1 | 0 | 1 | 2008 |
8 organizations
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