Cambiogenplasmid
Trade name: neovasculgen
Gene therapyexperimental
Cambiogenplasmid, marketed as Neovasculgen, is a gene therapy drug for treatment of peripheral artery disease, including critical limb ischemia; it delivers the gene encoding for vascular endothelial growth factor (VEGF). Neovasculogen is a plasmid encoding the CMV promoter and the 165 amino acid form of VEGF. It was developed by the Human Stem Cells Institute in Russia and approved in Russia in 2011. — Wikipedia
Clinical trial activity
6 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
2
Phase 3
1
Phase 4
2
Earliest trial started Feb 1, 2010 (NCT03068585)
Timeline
Indications
Approved for
Mechanism of action
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaCambiogenplasmid ↗
- WikipediaNeovasculgen ↗
Also known as
- neovasculgen
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06473740 | Phase 4 | Jun 20, 2024 | Amur State Medical Academy |
| NCT02538705 | N/A | Aug 1, 2015 | Human Stem Cell Institute, Russia, Pavlov First Saint Petersburg State Medical University, Vidnoe District Hospital |
| NCT02352649 | Phase 1/Phase 2 (Phase 2) | Apr 1, 2015 | Human Stem Cell Institute, Russia, Kazan Federal University |
| NCT02356809 | Phase 1/Phase 2 (Phase 2) | Mar 1, 2015 | Human Stem Cell Institute, Russia, Russian Academy of Medical Sciences |
| NCT02369809 | Phase 4 | Sep 1, 2012 | Human Stem Cell Institute, Russia |
| NCT03068585 | Phase 2/Phase 3 (Phase 3) | Feb 1, 2010 | Human Stem Cell Institute, Russia |
Showing 6 of 6 trials
Page 1 / 1
Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Human Stem Cell Institute, Russia | Academic/Hospital | 5 | 5 | 4 | 2010 |
| Amur State Medical Academy | Academic/Hospital | 1 | 1 | 1 | 2024 |
| Kazan Federal University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Pavlov First Saint Petersburg State Medical University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Russian Academy of Medical Sciences | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Vidnoe District Hospital | Academic/Hospital | 1 | 0 | 1 | 2015 |
6 organizations
Page 1 / 1