adenosine monophosphate
Small moleculeexperimental
Adenosine monophosphate (AMP) is a nucleotide, consisting of a phosphate group, the sugar ribose, and the nucleobase adenine. AMP is an activator of several enzymes in the tissues. In the glycolytic pathway, the enzyme phosphofructokinase is inhibited by ATP but the inhibition is reversed by AMP, the deciding factor for the reaction being the ratio between ATP and AMP. In medicine, AMP is used mainly as an alternative to adenosine for treatment of ischemia and as a tool compound to measure hyperresponsiveness of airways. — NCATS
Clinical trial activity
3 trials · 3 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
0
Phase 3
0
Phase 4
1
Earliest trial started Oct 1, 2003 (NCT00179010)
Timeline
2010s
- Jan 1, 2019
Earliest Phase 1 Sponsor(trial)
Indications
Approved for
Mechanism of action
- Unspecified targetOTHER
Unknown
- AdenosineSupplementation
adenosine
Chemistry & pharmacology
Loading structure…
SMILES
NC1=NC=NC2=C1N=CN2[C@@H]3O[C@H](COP(O)(O)=O)[C@@H](O)[C@H]3O- Mol. weight
- 347.2212 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaAdenosine monophosphate ↗
- NCATS415SHH325A ↗
- ChEMBLCHEMBL752 ↗
Also known as
- 5'-adenosine monophosphate
- 5'-adenosine monophosphate
- 5'-adenylic acid
- 5'-adenylic acid
- 5'-adenylic acid
- 5'-amp
- 5'-amp
- 5'-o-phosphonoadenosine
- 5'-o-phosphonoadenosine
- a-5mp
- a-5mp
- adenosine 5'-(dihydrogen phosphate)
- adenosine 5'-(dihydrogen phosphate)
- adenosine 5'-monophosphate
- adenosine 5'-monophosphate
- adenosine 5'-monophosphate
- adenosine-5'-monophosphate
- adenosine-5'-monophosphate
- adenosine-5'-monophosphoric acid
- adenosine-5'-monophosphoric acid
- adenosine-5'p
- adenosine-5'p
- adenosine 5'-phosphate
- adenosine 5'-phosphate
- adenosine 5'-phosphate
- adenosine monophosphate
- adenosine monophosphate
- adenosine monophosphate
- adenosine monophosphate
- adenosine monophosphate
- adenosine monophosphate
- adenosine phosphate
- adenosine phosphate
- adenosine phosphate
- adenosine phosphate
- adenosine phosphate
- adenosine phosphate
- adenosine phosphate
- adenosine phosphate
- adenosini phosphas
- adenosini phosphas
- adenovite
- adenyl
- adenyl
- adenylate
- adenylate
- adenylic acid
- adenylic acid
- adenylic acid
- ado5'p
- ado5'p
- amp
- amp
- amp
- fosfato de adenosina
- fosfato de adenosina
- my-b-den
- my-b-den
- pado
- pado
- phosaden
- phosaden
- phosphaden
- phosphaden
- phosphate d'adenosine
- phosphate d'adenosine
- phosphentaside
- vitamin b8
- vitamin b8
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03738943 | Early Phase 1 (Phase 1) | Feb 7, 2019 | Colorado State University |
| NCT02574975 | Phase 4 | Apr 1, 2015 | Southern Medical University |
| NCT00179010 | N/A | Oct 1, 2003 | Vanderbilt University |
Showing 3 of 3 trials
Page 1 / 1
Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Colorado State University | Academic/Hospital | 1 | 1 | 1 | 2019 |
| Southern Medical University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Vanderbilt University | Academic/Hospital | 1 | 1 | 1 | 2003 |
3 organizations
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