hydroxyapatite silica
Small moleculeexperimental
Clinical trial activity
24 trials · 25 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
3
Phase 3
2
Phase 4
5
Earliest trial started Apr 1, 2010 (NCT01626625)
Timeline
Indications
Approved for
Studied for
- Alveolar Bone Loss · Phase 4
- Alveolar Ridge Augmentation · Phase 3
- Cellulite · Phase 1
- Chronic Periodontitis · Phase 2
- Deficiency Diseases · Phase 4
- Dental Prosthesis · Phase 2/Phase 3
- Fractures, Bone · Phase 1
- Inflammation · Phase 4
- Nerve Sheath Neoplasms · Phase 4
- Periodontal Diseases · Phase 4
- Pulpitis · Phase 2/Phase 3
- Tooth · Phase 2
Mechanism of action
- OsteopontinTissue restoration
SPP1 tissue restoration
Chemistry & pharmacology
Loading structure…
SMILES
O=P([O-])([O-])[O-].O=P([O-])([O-])[O-].O=P([O-])([O-])[O-].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[Ca+2].[OH-]- Mol. weight
- 502.31 g/mol
- Chirality
- Achiral Molecule
- Inorganic
- Yes
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL2218916 ↗
Also known as
- alveograf
- alveograf
- calcium hydroxyapatite
- calcium hydroxyapatite
- calcium hydroxylapatite
- calcium hydroxylapatite
- durapatite
- durapatite
- hydroxyapatite
- hydroxyapatite
- hydroxyapatite
- hydroxyapatite silica
- hydroxylapatite
- hydroxylapatite
- ossopan
- ossopan
- ossopan 200
- ossopan 800
- periograf
- periograf
- win-40350
- win-40350
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07177053 | Phase 2 | Nov 30, 2025 | Government of Dubai |
| NCT07056855 | N/A | Jul 10, 2025 | Cairo University |
| NCT06896565 | N/A | Jun 1, 2025 | Cairo University |
| NCT06834464 | N/A | Dec 5, 2024 | National Research Center, Egypt |
| NCT06821724 | N/A | Dec 1, 2024 | National Research Center, Egypt |
| NCT07210281 | Phase 4 | Nov 1, 2024 | University of Opole |
| NCT06338241 | Phase 4 | Mar 2, 2024 | Universidad de Murcia, University of Santiago de Compostela |
| NCT07160101 | N/A | Mar 22, 2023 | SVS Institute of Dental Sciences |
| NCT05885035 | Phase 1 | Jan 1, 2023 | K. Kay Durairaj, MD, FACS, A Medical Corporation, Merz |
| NCT07028567 | N/A | Jan 1, 2023 | Tanta University |
| NCT05485662 | N/A | Sep 6, 2022 | Dr. Kurt Wolff GmbH & Co. KG, University of Texas, San Antonio |
| NCT05039723 | Phase 4 | Sep 1, 2021 | Main Line Center for Laser Surgery, Merz |
| NCT03681340 | N/A | Aug 7, 2018 | Dr. Kurt Wolff GmbH & Co. KG, University of Texas, San Antonio |
| NCT05812872 | Phase 3 | Jun 20, 2017 | Ain Shams University |
| NCT02532543 | N/A | Apr 30, 2016 | Dentsply International, University of North Carolina at Chapel Hill |
| NCT02711995 | N/A | Sep 1, 2015 | Cornell University |
| NCT02454088 | N/A | May 31, 2015 | Cosmetic Laser Dermatology, Goldman, Butterwick, Fitzpatrick and Groff, Merz |
| NCT02507596 | N/A | Apr 1, 2015 | Cairo University |
| NCT03046173 | N/A | May 31, 2014 | Deyang Stomatological Hospital |
| NCT02639572 | Phase 2 | Jan 1, 2014 | AzureBio, Madrid, Spain, SVS Institute of Dental Sciences |
Showing 20 of 24 trials
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Organizations
Research & Development (25)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Merz | For profit | 4 | 0 | 3 | 2010 |
| Cairo University | Academic/Hospital | 3 | 3 | 1 | 2015 |
| Dr. Kurt Wolff GmbH & Co. KG | For profit | 2 | 1 | 1 | 2018 |
| National Research Center, Egypt | Government | 2 | 2 | 1 | 2024 |
| SVS Institute of Dental Sciences | Academic/Hospital | 2 | 2 | 2 | 2014 |
| University of Texas, San Antonio | Academic/Hospital | 2 | 1 | 1 | 2018 |
| Ain Shams University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Azad University | Academic/Hospital | 1 | 1 | 1 | 2011 |
| AzureBio, Madrid, Spain | For profit | 1 | 0 | 1 | 2014 |
| Cornell University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Cosmetic Laser Dermatology | Academic/Hospital | 1 | 0 | 1 | 2015 |
| DeNova Research | For profit | 1 | 1 | 1 | 2010 |
| Dentsply International | For profit | 1 | 0 | 1 | 2016 |
| Deyang Stomatological Hospital | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Goldman, Butterwick, Fitzpatrick and Groff | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Government of Dubai | Government | 1 | 1 | 1 | 2025 |
| K. Kay Durairaj, MD, FACS, A Medical Corporation | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Main Line Center for Laser Surgery | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Tanta University | Academic/Hospital | 1 | 1 | 1 | 2023 |
| Universidad de Murcia | Academic/Hospital | 1 | 0 | 1 | 2024 |
25 organizations
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