trodusquemine
Small moleculeexperimental
Trodusquemine is an aminosterol that inhibits protein tyrosine phosphatase 1B (PTP1B) activity. The compound exhibits broad-spectrum antimicrobial activity and numerous regenerative, neuroprotective, anti-atherosclerotic, antitumor, antiangiogenic, antiobesity, and anxiolytic properties. Phase I clinical trials of trodusquemine have demonstrated good tolerability, but several planned phase II trials were halted due to financial difficulties of the developer. — Wikipedia
Clinical trial activity
4 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
0
Phase 3
0
Phase 4
0
Earliest trial started May 1, 2007 (NCT00509132)
Timeline
2000s
- Jan 1, 2007
Earliest Phase 1 Sponsor(trial)
Indications
Mechanism of action
- Protein-tyrosine phosphatase 1BINHIBITOR
PTPN1 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)[C@@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@H]4C[C@@H](NCCCNCCCCNCCCN)CC[C@]4(C)[C@H]3CC[C@]12C)OS(=O)(=O)O- Mol. weight
- 685.07 g/mol
- Lipinski Ro5
- 3 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTrodusquemine ↗
- ChEMBLCHEMBL508583 ↗
Also known as
- 3beta-n-1(spermine)-7alpha, 24r-dihydroxy-5alpha-cholestane 24-sulfate
- 3-n-1(spermine)-7, 24-dihydroxy-5-cholestane 24-sulfate
- msi1436
- msi 1436
- msi-1436
- msi-1436
- msi-1436c
- trodusquemine
- trodusquemine
- trodusquemine
- trodusquemine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02524951 | Phase 1 | Apr 1, 2016 | DepYmed Inc., Northwell Health |
| NCT00806338 | Phase 1 | Nov 1, 2008 | DGD Research, Genaera Corporation, PRACS |
| NCT00606112 | Phase 1 | Jan 1, 2008 | Allied Research International, DGD Research, Genaera Corporation |
| NCT00509132 | Phase 1 | May 1, 2007 | Genaera Corporation, IQVIA |
Showing 4 of 4 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Genaera Corporation | For profit | 3 | 3 | 1 | 2007 |
| DGD Research | For profit | 2 | 0 | 1 | 2008 |
| Allied Research International | For profit | 1 | 0 | 1 | 2008 |
| DepYmed Inc. | For profit | 1 | 0 | 1 | 2016 |
| IQVIA | For profit | 1 | 0 | 1 | 2007 |
| Northwell Health | Academic/Hospital | 1 | 1 | 1 | 2016 |
| PRACS | For profit | 1 | 0 | 1 | 2008 |
7 organizations
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