squalamine lactate
Squalamine was discovered in a search for anti-microbial compounds in the tissues of primitive vertebrates. The team speculated that animals with primitive immune systems, such as sharks and lampreys, might utilize antimicrobial compounds as a significant component of their immune repertoire. The dogfish shark was the first shark species studied since it was accessible for research purposes at the Mount Desert Marine Biological Laboratory. In addition, large numbers of dogfish are harvested annually for consumption and could provide sufficient tissue for extraction during the early stages of compound isolation and characterization. The chemical synthesis was developed by William A. Kinney and colleagues,. — Wikipedia
Clinical trial activity
3 trials · 7 clinical orgs · 0 marketing orgs
Earliest trial started Aug 1, 2004 (NCT00089830)
Timeline
2000s
- Jan 1, 2004
Earliest Phase 2 Sponsor(trial)
Indications
Studied for
Mechanism of action
- Sodium/hydrogen exchanger 3INHIBITOR
SLC9A3 inhibitor
Anti-angiogenic amino sterol
Chemistry & pharmacology
SMILES
CC(C)[C@@H](CC[C@@H](C)[C@H]1CC[C@H]2[C@@H]3[C@H](O)C[C@H]4C[C@@H](NCCCNCCCCN)CC[C@]4(C)[C@H]3CC[C@]12C)OS(=O)(=O)O.C[C@H](O)C(=O)O.O- Mol. weight
- 736.07 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3989689 ↗
- WikipediaSqualamine ↗
- ChEMBLCHEMBL2107782 ↗
Also known as
- msi-1256f
- msi-1256f
- msi-1256f
- squalamine lactate
- squalamine lactate
- squalamine lactate
- squalamine lactate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00333476 | Phase 2 | May 1, 2006 | Bascom Palmer Eye Institute, Charles Garcia, MD, P.A., Eye Foundation of Kansas City, Florida Eye Microsurgical Institute, Inc., Genaera Corporation, Ophthalmic Consultants of Long Island, Retina Associates of Western New York |
| NCT00094120 | Phase 2 | Oct 1, 2004 | Genaera Corporation |
| NCT00089830 | Phase 2 | Aug 1, 2004 | Genaera Corporation |
Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Genaera Corporation | For profit | 3 | 3 | 1 | 2004 |
| Bascom Palmer Eye Institute | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Charles Garcia, MD, P.A. | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Eye Foundation of Kansas City | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Florida Eye Microsurgical Institute, Inc. | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Ophthalmic Consultants of Long Island | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Retina Associates of Western New York | Academic/Hospital | 1 | 0 | 1 | 2006 |