mk-8457
Small moleculeexperimental
Clinical trial activity
3 trials · 1 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Oct 1, 2011 (NCT01446003)
Timeline
Indications
Mechanism of action
- Tyrosine-protein kinase SYKINHIBITOR
KSYK inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
Cc1cc(Nc2nccc(C(F)(F)F)n2)cc(-c2cnc([C@@]3(O)CC[C@H](C(=O)O)C(C)(C)C3)s2)c1- Mol. weight
- 506.55 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3685811 ↗
Also known as
- mk-8457
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01651936 | Phase 2 | Aug 1, 2012 | Merck |
| NCT01569152 | Phase 2 | May 1, 2012 | Merck |
| NCT01446003 | Phase 1 | Oct 1, 2011 | Merck |
Showing 3 of 3 trials
Page 1 / 1
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Merck | For profit | 3 | 3 | 2 | 2011 |
1 organizations
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