mapatumumab
mAbexperimental
Mapatumumab (HGS-ETR1) is an experimental human monoclonal antibody undergoing clinical trials for the treatment of cancer. It targets TRAIL-R1, also known as DR4, which is expressed on the surface of many tumor cell types. — Wikipedia
Clinical trial activity
7 trials · 3 clinical orgs · 0 marketing orgs
Phase 1
2
Phase 2
6
Phase 3
0
Phase 4
0
Earliest trial started Jun 1, 2004 (NCT00094848)
Timeline
Indications
Mechanism of action
- TRAIL receptor-1AGONIST
TNFRSF10A agonist
Mapatumumab, like the native ligand TRAIL, mediates apoptosis by binding to TRAIL-R1, leading to activation of the caspase cascade, cleavage of key intracellular signalling components and DNA and subsequent cell death.
- TRAIL receptor-1INHIBITOR
TNFRSF10A inhibitor
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaMapatumumab ↗
- ChEMBLCHEMBL2108621 ↗
Also known as
- hgs-etr1
- mapatumumab
- mapatumumab
- trail-r1 mab
- trm-1
- trm-1
- trm-1 hgs-etr1
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01258608 | Phase 2 | Feb 1, 2011 | GlaxoSmithKline, Human Genome Sciences |
| NCT01088347 | Phase 1/Phase 2 (Phase 2) | Mar 1, 2010 | Human Genome Sciences, University of Groningen |
| NCT00712855 | Phase 1 | Jun 1, 2008 | GlaxoSmithKline, Human Genome Sciences |
| NCT00583830 | Phase 2 | Jan 1, 2007 | GlaxoSmithKline, Human Genome Sciences |
| NCT00315757 | Phase 2 | May 1, 2006 | GlaxoSmithKline, Human Genome Sciences |
| NCT00092924 | Phase 2 | Sep 24, 2004 | GlaxoSmithKline, Human Genome Sciences |
| NCT00094848 | Phase 2 | Jun 1, 2004 | GlaxoSmithKline, Human Genome Sciences |
Showing 7 of 7 trials
Page 1 / 1
Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Human Genome Sciences | For profit | 7 | 6 | 2 | 2004 |
| GlaxoSmithKline | For profit | 6 | 0 | 2 | 2004 |
| University of Groningen | Academic/Hospital | 1 | 1 | 1 | 2010 |
3 organizations
Page 1 / 1