malic acid
Small moleculeexperimental
Malic acid is an organic compound with the molecular formula HO2CCH(OH)CH2CO2H. It is a dicarboxylic acid that is made by all living organisms, contributes to the sour taste of fruits, and is used as a food additive. Malic acid has two stereoisomeric forms, though only the L-isomer exists naturally. The salts and esters of malic acid are known as malates. The malate anion is a metabolic intermediate in the citric acid cycle. — Wikipedia
Clinical trial activity
7 trials · 11 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
3
Phase 3
2
Phase 4
1
Earliest trial started Jan 1, 2008 (NCT00678431)
Timeline
Indications
Approved for
Studied for
- Alzheimer Disease · Phase 3
- Anti-Infective Agents, Local · Phase 2
- Carcinoma, Non-Small-Cell Lung · Phase 2
- COVID-19 · Phase 2
- Depression · Phase 2/Phase 3
- Hypertension · Phase 2/Phase 3
- Immune System · Phase 2
- Immunologic Factors · Phase 2
- Lung Diseases · Phase 2
- Palliative Care · Phase 2
- Quality of Life · Phase 4
- Sjogren's Syndrome · Phase 4
- Xerostomia · Phase 4
Mechanism of action
- Unspecified targetUnclear
Unclear
Chemistry & pharmacology
Loading structure…
SMILES
O=C(O)CC(O)C(=O)O- Mol. weight
- 134.09 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaMalic acid ↗
- ChEMBLCHEMBL1455497 ↗
Also known as
- calcium (hydroxy-1-malate) hexahydrate
- e296
- e296
- malate
- malate
- malate
- malic acid
- malic acid
- malic acid
- malic acid
- malic acid
- malic acid, calcium salt, (1:1), (s)-isomer
- malic acid, disodium salt
- malic acid, disodium salt, (r)-isomer
- malic acid, disodium salt, (s)-isomer
- malic acid, magnesium salt (2:1)
- malic acid, monopotassium salt, (+-)-isomer
- malic acid, potassium salt, (r)-isomer
- malic acid, (r)-isomer
- malic acid, sodium salt, (+-)-isomer
- salivix
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05778227 | N/A | Nov 16, 2021 | Dow University of Health Sciences |
| NCT04756986 | N/A | Jan 1, 2021 | Alexandria University |
| NCT04701502 | Phase 2 | Nov 9, 2020 | Catalysis SL |
| NCT03578900 | Phase 4 | Jan 1, 2013 | Dentaid, University of Lisbon |
| NCT01652001 | Phase 2/Phase 3 (Phase 3) | Jan 1, 2011 | Universidad Carlos III Madrid, University of Granada |
| NCT01210053 | Phase 2 | Sep 1, 2010 | People's Liberation Army of China |
| NCT00678431 | Phase 3 | Jan 1, 2008 | Alzheimer's Association, Department of Veteran Affairs, Icahn School of Medicine at Mount Sinai |
Showing 7 of 7 trials
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Organizations
Research & Development (11)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Alexandria University | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Alzheimer's Association | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Catalysis SL | For profit | 1 | 1 | 1 | 2020 |
| Dentaid | Academic/Hospital | 1 | 0 | 1 | 2013 |
| Department of Veteran Affairs | Government | 1 | 1 | 1 | 2008 |
| Dow University of Health Sciences | Academic/Hospital | 1 | 1 | 1 | 2021 |
| Icahn School of Medicine at Mount Sinai | Academic/Hospital | 1 | 0 | 1 | 2008 |
| People's Liberation Army of China | Government | 1 | 1 | 1 | 2010 |
| Universidad Carlos III Madrid | Academic/Hospital | 1 | 0 | 1 | 2011 |
| University of Granada | Academic/Hospital | 1 | 1 | 1 | 2011 |
| University of Lisbon | Academic/Hospital | 1 | 1 | 1 | 2013 |
11 organizations
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