tryptophan
Small moleculeexperimental
Tryptophan is alpha-aminoacid that is used in the biosynthesis of proteins. It is essential aminoacid in humans, meaning the body cannot synthesize and it must be obtained from the diet. Tryptophan is a precursor of serotonin, and as such is sold over the counter in many countries as a dietary supplement for use as an antidepressant, anxiolytic and sleep aid, however application of tryptophan in these indications is not approved by FDA. — NCATS
Clinical trial activity
32 trials · 37 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
10
Phase 3
3
Phase 4
1
Earliest trial started Mar 1, 1997 (NCT00000324)
Timeline
Indications
Studied for
- Alzheimer Disease · Phase 4
- Behavior · Early Phase 1
- Blood Glucose · Early Phase 1
- Cocaine-Related Disorders · Phase 2
- Coronary Artery Disease · Phase 2
- Coronary Disease · Phase 2
- Diet · Early Phase 1
- Drug-Related Side Effects and Adverse Reactions · Phase 2
- General Surgery · Phase 3
- Healthy Volunteers · Phase 2
- Heart Defects, Congenital · Phase 2
- Heart Diseases · Phase 2
- Heart Valve Diseases · Phase 2
- Metformin · Early Phase 1
- Myocardial Ischemia · Phase 2
- Neoplasms · Phase 3
- Obesity · Phase 2
- Psychotic Disorders · Phase 1/Phase 2
- Quality of Life · Phase 2
- Schizophrenia · Phase 2/Phase 3
- Thiamine · Phase 2
- Tryptophan · Phase 2
Mechanism of action
- tryptophanSupplementation
tryptophan supplementation
Chemistry & pharmacology
Loading structure…
SMILES
N[C@@H](CC1=CNC2=C1C=CC=C2)C(O)=O- Mol. weight
- 204.2252 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTryptophan ↗
- NCATS8DUH1N11BX ↗
- ChEMBLCHEMBL54976 ↗
Also known as
- (2s)-2-amino-3-(1h-indol-3-yl)propanoic acid
- (2s)-2-amino-3-(1h-indol-3-yl)propanoic acid
- gppe pdr sach
- l-tryptophan
- l-tryptophan
- l-tryptophan
- l-tryptophan
- l-tryptophan
- l-tryptophan
- l-(-)-tryptophan
- l-(-)-tryptophan
- l-(−)-tryptophan
- l-(−)-tryptophan
- l-tryptophane
- l-β-3-indolylalanine
- l-β-3-indolylalanine
- optimax
- optimax
- optimax wv
- pacitron
- pacitron
- (s)-alpha-amino-beta-(3-indolyl)-propionic acid
- (s)-alpha-amino-beta-(3-indolyl)-propionic acid
- (s)-tryptophan
- (s)-tryptophan
- (s)-α-amino-1h-indole-3-propanoic acid
- (s)-α-amino-1h-indole-3-propanoic acid
- trp
- trp
- tryptophan
- tryptophan
- tryptophan
- tryptophan
- tryptophan
- tryptophan
- tryptophan
- tryptophane
- w
- w
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT07272668 | N/A | Nov 29, 2025 | University of Toronto |
| NCT07013656 | N/A | Jun 28, 2025 | University of Adelaide |
| NCT06414330 | N/A | Jun 1, 2024 | Assiut University |
| NCT06283706 | N/A | Jun 1, 2024 | Canadian Institutes of Health Research (CIHR), University of Toronto |
| NCT06089811 | N/A | Oct 10, 2023 | Katholieke Universiteit Leuven |
| NCT05576038 | N/A | Nov 1, 2022 | McMaster University |
| NCT05032729 | N/A | Nov 6, 2021 | CQUniversity Australia, PepsiCo |
| NCT04041934 | N/A | Nov 1, 2019 | University Clermont Auvergne |
| NCT04117191 | N/A | Oct 1, 2019 | Tzu Chi University |
| NCT04505800 | N/A | Sep 1, 2019 | National Yang-Ming University |
| NCT04013555 | Phase 1/Phase 2 (Phase 2) | Aug 1, 2019 | University of Maryland |
| NCT03341286 | Phase 2 | Nov 30, 2017 | Faculdade de Medicina do ABC |
| NCT03310034 | N/A | Nov 1, 2017 | Maastricht University |
| NCT03059862 | N/A | Aug 1, 2017 | Canadian Institutes of Health Research (CIHR), McMaster University, National Research Agency, France |
| NCT03082716 | Phase 2 | Sep 19, 2016 | King Faisal University |
| NCT02618824 | Phase 2 | Dec 1, 2015 | University of Indonesia |
| NCT02223299 | N/A | Nov 1, 2015 | Department of Veteran Affairs |
| NCT03288077 | N/A | Jun 30, 2015 | PepsiCo |
| NCT02402179 | N/A | Mar 31, 2015 | University of Toronto |
| NCT02067975 | Phase 2/Phase 3 (Phase 3) | Sep 1, 2014 | Mitsubishi Tanabe, National Institute of Mental Health (NIMH), University of Maryland |
Showing 20 of 32 trials
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Organizations
Research & Development (37)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Toronto | Academic/Hospital | 4 | 4 | 1 | 2013 |
| Canadian Institutes of Health Research (CIHR) | Academic/Hospital | 2 | 0 | 1 | 2017 |
| McMaster University | Academic/Hospital | 2 | 2 | 1 | 2017 |
| PepsiCo | For profit | 2 | 2 | 1 | 2015 |
| University of Bern | Academic/Hospital | 2 | 2 | 1 | 2014 |
| University of Maryland | Academic/Hospital | 2 | 2 | 2 | 2014 |
| Assiut University | Academic/Hospital | 1 | 1 | 1 | 2024 |
| CQUniversity Australia | Academic/Hospital | 1 | 0 | 1 | 2021 |
| Department of Veteran Affairs | Government | 1 | 1 | 1 | 2015 |
| DSM | For profit | 1 | 1 | 1 | 2010 |
| Essential Pharmaceuticals, LLC | For profit | 1 | 0 | 1 | 2012 |
| Faculdade de Medicina do ABC | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Fundació Sant Joan de Déu | Academic/Hospital | 1 | 1 | 1 | 2012 |
| Harvard University | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Johns Hopkins University | Academic/Hospital | 1 | 0 | 1 | 1997 |
| Katholieke Universiteit Leuven | Academic/Hospital | 1 | 1 | 1 | 2023 |
| King Faisal University | Academic/Hospital | 1 | 1 | 1 | 2016 |
| Lavilabor Natural Products Ltd | For profit | 1 | 1 | 1 | 2010 |
| Maastricht University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Mitsubishi Tanabe | For profit | 1 | 0 | 1 | 2014 |
37 organizations
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