kx2-391
Small moleculeexperimental
Clinical trial activity
10 trials · 8 clinical orgs · 0 marketing orgs
Phase 1
6
Phase 2
5
Phase 3
2
Phase 4
0
Earliest trial started Oct 1, 2007 (NCT00646139)
Timeline
Indications
Approved for
Studied for
Mechanism of action
- Tyrosine-protein kinase SRCINHIBITOR
SRC inhibitor
Targets the peptide substrate-binding site and is a non-ATP competitive inhibitor.
Chemistry & pharmacology
Loading structure…
SMILES
O=C(Cc1ccc(-c2ccc(OCCN3CCOCC3)cc2)cn1)NCc1ccccc1- Mol. weight
- 431.54 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Topical
- Availability
- Prescription Only
Oral
No
Parenteral
No
Topical
Yes
First in class
Sources
- ChEMBLCHEMBL571546 ↗
Also known as
- kx-01
- kx2-391
- kx2-391
- kx2-391
- kx2-391
- n-benzyl-2-(5-(4-(2-morpholinoethoxy)phenyl)pyridin-2-yl)acetamide
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03575780 | Phase 1 | Aug 31, 2018 | Athenex, Inc., TKL Research |
| NCT03285490 | Phase 3 | Sep 15, 2017 | Athenex, Inc. |
| NCT03285477 | Phase 3 | Sep 15, 2017 | Athenex, Inc. |
| NCT02838628 | Phase 2 | Apr 1, 2016 | Athenex, Inc. |
| NCT02337205 | Phase 1 | Dec 1, 2014 | Athenex, Inc. |
| NCT01397799 | Phase 1 | Dec 1, 2013 | Athenex, Inc., State University of New York, Buffalo |
| NCT01764087 | Phase 1/Phase 2 (Phase 2) | Dec 1, 2012 | Hanmi Pharmaceutical, Seoul National University |
| NCT01074138 | Phase 2 | Feb 1, 2010 | Athenex, Inc., Johns Hopkins University |
| NCT00658970 | Phase 1 | Nov 1, 2007 | Athenex, Inc., Temple University, University of Texas at Houston |
| NCT00646139 | Phase 1 | Oct 1, 2007 | State University of New York, Buffalo |
Showing 10 of 10 trials
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Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Athenex, Inc. | For profit | 8 | 8 | 3 | 2007 |
| State University of New York, Buffalo | Academic/Hospital | 2 | 1 | 1 | 2007 |
| Hanmi Pharmaceutical | For profit | 1 | 1 | 1 | 2012 |
| Johns Hopkins University | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Seoul National University | Academic/Hospital | 1 | 0 | 1 | 2012 |
| Temple University | Academic/Hospital | 1 | 0 | 1 | 2007 |
| TKL Research | For profit | 1 | 0 | 1 | 2018 |
| University of Texas at Houston | Academic/Hospital | 1 | 0 | 1 | 2007 |
8 organizations
Page 1 / 1