josamycin
Small moleculeexperimental
Clinical trial activity
1 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
1
Phase 3
1
Phase 4
0
Earliest trial started Jul 1, 2008 (NCT00718705)
Timeline
2000s
- Jan 1, 2008
Earliest Phase 3 Sponsor(trial)
Indications
Studied for
Mechanism of action
- 50S ribosomal protein L2INHIBITOR
rplB inhibitor
- Bacterial 70S ribosomeINHIBITOR
Bacterial 70S ribosome inhibitor
23S ribosomal RNA
- 30S ribosomal protein S2 (rpsB) ↗
- 50S ribosomal protein L4 (rplD) ↗
- 30S ribosomal protein S15 (rpsO) ↗
- 30S ribosomal protein S16 (rpsP) ↗
- 30S ribosomal protein S17 (rpsQ) ↗
- 30S ribosomal protein S18 (rpsR) ↗
- 30S ribosomal protein S19 (rpsS) ↗
- 30S ribosomal protein S20 (rpsT) ↗
- 30S ribosomal protein S21 (rpsU) ↗
- 30S ribosomal protein S3 (rpsC) ↗
- 30S ribosomal protein S4 (rpsD) ↗
- 30S ribosomal protein S5 (rpsE) ↗
- 30S ribosomal protein S6 (rpsF) ↗
- 30S ribosomal protein S7 (rpsG) ↗
- 30S ribosomal protein S8 (rpsH) ↗
- 30S ribosomal protein S9 (rpsI) ↗
- 50S ribosomal protein L35 (rpmI) ↗
- 50S ribosomal protein L36 2 (ykgO) ↗
- 50S ribosomal protein L36 (rpmJ) ↗
- 50S ribosomal protein L3 (rplC) ↗
- 50S ribosomal protein L5 (rplE) ↗
- 50S ribosomal protein L6 (rplF) ↗
- 50S ribosomal protein L7/L12 (rplL) ↗
- 30S ribosomal protein S1 (rpsA) ↗
- 30S ribosomal protein S10 (rpsJ) ↗
- 30S ribosomal protein S11 (rpsK) ↗
- 30S ribosomal protein S12 (rpsL) ↗
- 30S ribosomal protein S13 (rpsM) ↗
- 30S ribosomal protein S14 (rpsN) ↗
- 50S ribosomal protein L10 (rplJ) ↗
- 50S ribosomal protein L11 (rplK) ↗
- 50S ribosomal protein L13 (rplM) ↗
- 50S ribosomal protein L14 (rplN) ↗
- 50S ribosomal protein L15 (rplO) ↗
- 50S ribosomal protein L16 (rplP) ↗
- 50S ribosomal protein L17 (rplQ) ↗
- 50S ribosomal protein L18 (rplR) ↗
- 50S ribosomal protein L19 (rplS) ↗
- 50S ribosomal protein L1 (rplA) ↗
- 50S ribosomal protein L20 (rplT) ↗
- 50S ribosomal protein L21 (rplU) ↗
- 50S ribosomal protein L22 (rplV) ↗
- 50S ribosomal protein L23 (rplW) ↗
- 50S ribosomal protein L24 (rplX) ↗
- 50S ribosomal protein L25 (rplY) ↗
- 50S ribosomal protein L27 (rpmA) ↗
- 50S ribosomal protein L28 (rpmB) ↗
- 50S ribosomal protein L29 (rpmC) ↗
- 50S ribosomal protein L2 (rplB) ↗
- 50S ribosomal protein L30 (rpmD) ↗
- 50S ribosomal protein L31 type B (ykgM) ↗
- 50S ribosomal protein L31 (rpmE) ↗
- 50S ribosomal protein L32 (rpmF) ↗
- 50S ribosomal protein L33 (rpmG) ↗
- 50S ribosomal protein L34 (rpmH) ↗
Chemistry & pharmacology
Loading structure…
SMILES
CO[C@@H]1[C@@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](OC(=O)CC(C)C)[C@H](C)O3)[C@H](N(C)C)[C@H]2O)[C@@H](CC=O)C[C@@H](C)[C@@H](O)/C=C/C=C/C[C@@H](C)OC(=O)C[C@H]1OC(C)=O- Mol. weight
- 828.01 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL224436 ↗
Also known as
- antibiotic yl-704 a3
- antibiotic yl-704 a3
- en-141
- en-141
- iosalide
- jm
- jm
- josacine
- josamicina
- josamicina
- josamina
- josamycin
- josamycin
- josamycin
- josamycin
- josamycin
- josamycin
- josamycin
- josamycin
- josamycine
- josamycine
- josamycin propionate
- josamycin propionate
- josamycinum
- josamycinum
- kitasamycin a3
- kitasamycin a3
- leucomycin a3
- leucomycin a3
- leucomycin a3
- leucomycin v 3-acetate 4(b)-(3-methylbutanoate)
- leucomycin v 3-acetate 4(b)-(3-methylbutanoate)
- leucomycin v 3-acetate 4b-(3-methylbutanoate)
- leucomycin v 3-acetate 4b-(3-methylbutanoate)
- leucomycin v, 3-acetate 4b-(3-methylbutanoate)
- leucomycin v, 3-acetate 4b-(3-methylbutanoate)
- leucomycin v 3-acetate 4(beta)-(3-methylbutanoate)
- leucomycin v 3-acetate 4(beta)-(3-methylbutanoate)
- leucomycin v, 3-acetate 4(sup b)-(3-methylbutanoate)
- leucomycin v, 3-acetate 4(sup b)-(3-methylbutanoate)
- leucomycin v, 3-acetate 4(sup beta)-(3-methylbutanoate)
- leucomycin v, 3-acetate 4(sup beta)-(3-methylbutanoate)
- turimycin a5
- turimycin a5
- turimycin a5
- yl-704 a3
- yl-704 a3
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00718705 | Phase 3 | Jul 1, 2008 | Bayer, University of Paris |
Showing 1 of 1 trials
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Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Bayer | For profit | 1 | 0 | 1 | 2008 |
| University of Paris | Academic/Hospital | 1 | 1 | 1 | 2008 |
2 organizations
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