istaroxime
Small moleculeexperimental
Istaroxime is an investigational drug under development for treatment of acute decompensated heart failure — Wikipedia
Clinical trial activity
8 trials · 19 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
5
Phase 3
0
Phase 4
0
Earliest trial started Aug 1, 2006 (NCT00616161)
Timeline
Indications
Mechanism of action
Sarcoplasmic/endoplasmic reticulum calcium ATPase 2 activator
ATP1A1 inhibitor
- Sodium/potassium-transporting ATPaseINHIBITOR
Sodium/potassium-transporting ATPase inhibitor
- Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1) ↗
- Sodium/potassium-transporting ATPase subunit beta-2 (ATP1B2) ↗
- Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1) ↗
- Sodium/potassium-transporting ATPase subunit alpha-2 (ATP1A2) ↗
- Sodium/potassium-transporting ATPase subunit beta-3 (ATP1B3) ↗
- Sodium/potassium-transporting ATPase subunit alpha-3 (ATP1A3) ↗
- Sodium/potassium-transporting ATPase subunit alpha-4 (ATP1A4) ↗
- Sodium/potassium-transporting ATPase subunit gamma (FXYD2) ↗
- Sodium/potassium-transporting ATPase alpha-1 chain
- Sodium/potassium-transporting ATPase beta-3 chain
- Sodium/potassium-transporting ATPase subunit alpha-2/beta-1
- Sodium/potassium-transporting ATPase subunit alpha-1/beta-1
- Sodium/potassium-transporting ATPase subunit alpha-2/beta-3
- Sodium/potassium-transporting ATPase subunit alpha-2/beta-2
- Sodium/potassium-transporting ATPase beta-1 chain
Chemistry & pharmacology
Loading structure…
SMILES
CCCON=C1CC[C@@]2(C)[C@H](C1)C(=O)C[C@@H]1[C@@H]2CC[C@]2(C)C(=O)CC[C@@H]12- Mol. weight
- 359.51 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3989692 ↗
- WikipediaIstaroxime ↗
- ChEMBLCHEMBL3138451 ↗
- ChEMBLCHEMBL2093999 ↗
Also known as
- istaroxime
- istaroxime
- istaroxime
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05975021 | Phase 1/Phase 2 (Phase 2) | Dec 1, 2023 | Windtree Therapeutics |
| NCT04325035 | Phase 2 | Jun 30, 2020 | Momentum Research, Inc., University of Brescia, Windtree Therapeutics |
| NCT02617446 | Phase 2 | Dec 1, 2015 | CVie Therapeutics Co. Ltd., Lee's Pharmaceutical |
| NCT02772068 | Early Phase 1 (Phase 1) | Sep 1, 2015 | The University of Texas, Dallas |
| NCT02477449 | Phase 1 | May 1, 2015 | CVie Therapeutics Co. Ltd., Lee's Pharmaceutical |
| NCT00869115 | Phase 1 | Jun 1, 2009 | Debiopharm |
| NCT00838253 | Phase 2 | Jun 1, 2009 | Debiopharm |
| NCT00616161 | Phase 2 | Aug 1, 2006 | Alexandria University, CC Iliescu Heart Disease Institute, Bucharest, Emergency Hospital Loreasca, Bucharest, Hospital bieganskieko, Lodz, Insitutul de Boli Cardiovasculare C.C. Iliescu Bucuresti, Bucharest - ROMANIA, Institute of Cardiology, Warsaw, Poland, Iv Military Hospital, Wroclaw, Leadiant Biosciences, Inc., MDS Pharma, Medical University of Warsaw, Northwestern University, University of Athens |
Showing 8 of 8 trials
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Organizations
Research & Development (19)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| CVie Therapeutics Co. Ltd. | For profit | 2 | 0 | 2 | 2015 |
| Debiopharm | For profit | 2 | 2 | 2 | 2009 |
| Lee's Pharmaceutical | For profit | 2 | 2 | 2 | 2015 |
| Windtree Therapeutics | For profit | 2 | 2 | 1 | 2020 |
| Alexandria University | Academic/Hospital | 1 | 0 | 1 | 2006 |
| CC Iliescu Heart Disease Institute, Bucharest | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Emergency Hospital Loreasca, Bucharest | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Hospital bieganskieko, Lodz | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Insitutul de Boli Cardiovasculare C.C. Iliescu Bucuresti, Bucharest - ROMANIA | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Institute of Cardiology, Warsaw, Poland | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Iv Military Hospital, Wroclaw | Government | 1 | 0 | 1 | 2006 |
| Leadiant Biosciences, Inc. | For profit | 1 | 1 | 1 | 2006 |
| MDS Pharma | For profit | 1 | 0 | 1 | 2006 |
| Medical University of Warsaw | Academic/Hospital | 1 | 0 | 1 | 2006 |
| Momentum Research, Inc. | For profit | 1 | 0 | 1 | 2020 |
| Northwestern University | Academic/Hospital | 1 | 0 | 1 | 2006 |
| The University of Texas, Dallas | Academic/Hospital | 1 | 1 | 1 | 2015 |
| University of Athens | Academic/Hospital | 1 | 0 | 1 | 2006 |
| University of Brescia | Academic/Hospital | 1 | 0 | 1 | 2020 |
19 organizations
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