leukotriene e4
Leukotriene E4 (LTE4) is a cysteinyl leukotriene involved in inflammation. It is known to be produced by several types of white blood cells, including eosinophils, mast cells, tissue macrophages, and basophils, and recently was also found to be produced by platelets adhering to neutrophils. It is formed from the sequential conversion of LTC4 to LTD4 and then to LTE4, which is the final and most stable cysteinyl leukotriene. Compared to the short half lives of LTC4 and LTD4, LTE4 is relatively stable and accumulates in breath condensation, in plasma, and in urine, making it the dominant cysteinyl leukotriene detected in biologic fluids. Therefore, measurements of LTE4, especially in the urine, are commonly monitored in clinical research studies. — Wikipedia
Clinical trial activity
3 trials · 3 clinical orgs · 0 marketing orgs
Earliest trial started May 1, 2012 (NCT01841164)
Timeline
No events for the selected filters.
Indications
Approved for
Studied for
Mechanism of action
- Leukotriene B4 receptor 1AGONIST
LTB4R agonist
- Leukotriene B4 receptor 2AGONIST
LTB4R2 agonist
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaLeukotriene E4 ↗
Also known as
- 5s-hydroxy-6r-(s-cysteinylglycinyl)-7e,9e,11e,14z-eicosatetraenoic acid
- 5s-hydroxy-6r-(s-cysteinylglycinyl)-7e,9e,11e,14z-eicosatetraenoic acid
- leukotriene d4
- leukotriene d4
- leukotriene d4
- leukotriene e4
- leukotriene e4
- ltd4
- ltd4
- (r-(r*,s*-(e,e,z,z)))-n-(s-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-l-cysteinyl)glycine
- (r-(r*,s*-(e,e,z,z)))-n-(s-(1-(4-carboxy-1-hydroxybutyl)-2,4,6,9-pentadecatetraenyl)-l-cysteinyl)glycine
- s-{(1r,2e,4e,6z,9z)-1-[(1s)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-l-cysteinylglycine
- s-{(1r,2e,4e,6z,9z)-1-[(1s)-4-carboxy-1-hydroxybutyl]pentadeca-2,4,6,9-tetraen-1-yl}-l-cysteinylglycine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02574975 | Phase 4 | Apr 1, 2015 | Southern Medical University |
| NCT01963741 | N/A | Nov 1, 2012 | Guangzhou Medical University |
| NCT01841164 | N/A | May 1, 2012 | Karolinska Institute |
Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Guangzhou Medical University | Academic/Hospital | 1 | 1 | 1 | 2012 |
| Karolinska Institute | Academic/Hospital | 1 | 1 | 1 | 2012 |
| Southern Medical University | Academic/Hospital | 1 | 1 | 1 | 2015 |