indiplon
Small moleculeexperimental
Indiplon is a unmarketed nonbenzodiazepine, hypnotic sedative that was developed in two formulations—an immediate-release formulation for sleep onset, and a modified-release version for sleep maintenance. — Wikipedia
Clinical trial activity
2 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
2
Phase 3
2
Phase 4
0
Earliest trial started Nov 1, 2005 (NCT00232167)
Timeline
2000s
- Jan 1, 2005
Earliest Phase 3 Sponsor(trial)
Indications
Mechanism of action
- GABA receptor alpha-1 subunitPOSITIVE ALLOSTERIC MODULATOR
GABRA1 positive allosteric modulator
Chemistry & pharmacology
Loading structure…
SMILES
CC(=O)N(C)c1cccc(-c2ccnc3c(C(=O)c4cccs4)cnn23)c1- Mol. weight
- 376.44 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaIndiplon ↗
- ChEMBLCHEMBL262075 ↗
Also known as
- cl-285489
- cl-285489
- indiplon
- indiplon
- indiplon
- indiplon
- indiplon
- nbi 34060
- nbi-34060
- nbi-34060
- nbi-34060
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00525941 | Phase 3 | Sep 1, 2007 | Clinilabs, Neurocrine Biosciences |
| NCT00232167 | Phase 3 | Nov 1, 2005 | Neurocrine Biosciences |
Showing 2 of 2 trials
Page 1 / 1
Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Neurocrine Biosciences | For profit | 2 | 2 | 1 | 2005 |
| Clinilabs | For profit | 1 | 0 | 1 | 2007 |
2 organizations
Page 1 / 1