imidapril

Trade name: tanatril

Small moleculeexperimental

Imidapril, sold under the brand name Tanatril among others, is an ACE inhibitor used as an antihypertensive drug and for the treatment of chronic heart failure. — Wikipedia

Clinical trial activity

3 trials · 3 clinical orgs · 0 marketing orgs

Phase 1
0
Phase 2
3
Phase 3
2
Phase 4
0

Earliest trial started Mar 1, 2008 (NCT00644475)

Timeline

2000s

  1. Jan 1, 2008

    Earliest Phase 3 Sponsor(trial)

  2. Jan 1, 2009

    Earliest Phase 2 Sponsor(trial)

Indications

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CCOC(=O)[C@H](CCc1ccccc1)N[C@@H](C)C(=O)N1C(=O)N(C)C[C@H]1C(=O)O
Mol. weight
405.45 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No
Delivery
Oral

Oral

Yes

Parenteral

No

Topical

No

Prodrug

Sources

Also known as

  • 1-methyl-3-(2-(n-(1-ethoxycarbonyl-3-phenylpropyl)amino)propionyl)-2-oxoimidazolidine-4-carboxylic acid
  • 4-imidazolidinecarboxylic acid, 3-(2-((1-(ethoxycarbonyl)-3-phenylpropyl)amino)-1-oxopropyl)-1-methyl-2-oxo-, monohydrochloride, (4s-(3(r*(r*)),4r*))-
  • imidapril
  • imidapril
  • imidapril
  • imidapril
  • imidapril
  • imidapril
  • imidapril
  • imidaprilat
  • imidapril hcl
  • imidapril hcl
  • imidapril hcl
  • imidapril hcl
  • imidapril hydrochloride
  • imidapril hydrochloride
  • imidapril hydrochloride
  • imidapril hydrochloride
  • imidapril hydrochloride
  • ta 6366
  • ta-6366
  • ta-6366
  • tanatril
  • tanatril
  • tanatril
  • tanatril

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT01230034Phase 3Oct 1, 2010University of Pavia
NCT00890279Phase 2Jul 1, 2009Government of Japan, Teikyo University
NCT00644475Phase 3Mar 1, 2008University of Pavia
Showing 3 of 3 trials
Page 1 / 1

Organizations

Research & Development (3)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
University of PaviaAcademic/Hospital2212008
Government of JapanGovernment1112009
Teikyo UniversityAcademic/Hospital1012009
3 organizations
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