helium
Approved
Jul 14, 2013
Helium is a chemical element with symbol He and atomic number 2. It is inert, non-toxic odorless gas. In medicine, helium is used to help the flow of oxygen in diseases such as bronchitis, or to assist breathing if part of lungs fails to expand. The mixture of helium and oxygen is known as heliox. — NCATS
Clinical trial activity
22 trials · 22 clinical orgs · 16 marketing orgs
Earliest trial started Dec 1, 2004 (NCT00116584)
Timeline
2000s
2010s
- Jul 14, 2013
Norco — Earliest FDA Approval
- Jul 14, 2013
Norco — NDA Secondary Org
- Jul 14, 2013
Norco — NDA Organization
- Jul 20, 2013
Airgas Usa Llc — NDA Secondary Org
- Jul 23, 2013
Air Products And Chemicals Inc — NDA Secondary Org
- Aug 5, 2013
Praxair — NDA Secondary Org
- Sep 7, 2013
Air Liquide — NDA Secondary Org
- Mar 4, 2014
Linde AG — NDA Secondary Org
- Mar 4, 2014
BOC International — NDA Secondary Org
- Feb 20, 2016
Nexair — Marketing Organization
- Feb 20, 2016
Nexair — NDA Secondary Org
- Apr 23, 2018
A-Ox Welding Supply Co, Inc. — NDA Secondary Org
- Oct 16, 2018
Matheson Tri-Gas Inc — Marketing Organization
- Jul 14, 2019
Roberts Pharmaceutical — Marketing Organization
- Jul 14, 2019
Takeda — NDA Secondary Org
- Aug 18, 2019
A G L Welding Supply Co Inc — Marketing Organization
- Aug 18, 2019
A G L Welding Supply Co Inc — NDA Secondary Org
- Oct 27, 2019
Ilmo Products Company — Marketing Organization
- Oct 27, 2019
Ilmo Products Company — NDA Secondary Org
2020s
- Jun 27, 2020
Westair Gases & Equipment Inc — Marketing Organization
- Jun 27, 2020
Westair Gases & Equipment Inc — NDA Secondary Org
- Jul 26, 2021
General Air Service & Supply Company — Marketing Organization
- Jul 26, 2021
General Air Service & Supply Company — NDA Secondary Org
Indications
Approved for
Studied for
- Airway Obstruction · Phase 1/Phase 2
- Bronchiolitis · Phase 3
- Bronchitis, Chronic · Phase 2/Phase 3
- Dyspnea · Phase 1/Phase 2
- Healthy Volunteers · Phase 1
- Infant, Premature · Phase 1/Phase 2
- Pulmonary Diffusing Capacity · Phase 1
- Pulmonary Disease, Chronic Obstructive · Phase 3
- Respiratory Distress Syndrome · Phase 1/Phase 2
- Respiratory Insufficiency · Phase 4
- Respiratory Syncytial Virus Infections · Phase 3
- Sleep Apnea, Obstructive · Phase 2
- Status Asthmaticus · Phase 2
Mechanism of action
- LungOTHER
Lung
Approval history
- approvedJul 14, 2013
Chemistry & pharmacology
SMILES
[He]- Mol. weight
- 4.002602 g/mol
- Chirality
- Achiral Molecule
- Inorganic
- Yes
- Polymer
- No
- Delivery
- Topical
- Availability
- Prescription Only
Oral
No
Parenteral
No
Topical
Yes
Sources
- WikipediaHelium ↗
- NCATS206GF3GB41 ↗
- ChEMBLCHEMBL1796997 ↗
Also known as
- atomic helium
- atomic helium
- atomic helium
- e939
- e939
- [he]
- [he]
- helium
- helium
- helium
- helium
- helium
- helium
- helium
- helium
- helium
- helium
- helium; molecular oxygen
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT05307276 | N/A | Apr 1, 2022 | University of Nice Sophia Antipolis |
| NCT04404816 | Phase 1/Phase 2 (Phase 2) | Jan 31, 2017 | European Society for Paediatric Research, Poznan University |
| NCT02995590 | Phase 1 | Jul 1, 2016 | University of Virginia |
| NCT02745951 | N/A | Apr 30, 2016 | Unity Health Toronto |
| NCT03171142 | Phase 3 | May 1, 2015 | Mansoura University |
| NCT02154568 | N/A | Nov 1, 2013 | University of Virginia |
| NCT01759316 | N/A | Dec 31, 2012 | People's Liberation Army of China |
| NCT01498432 | Phase 4 | Jan 1, 2012 | University of London |
| NCT01155310 | Phase 3 | May 1, 2010 | Air Liquide, University of Lausanne |
| NCT01355809 | Phase 2 | Dec 1, 2009 | Air Liquide, University of Hamburg |
| NCT02135900 | Phase 2 | Dec 1, 2009 | Northwell Health, State University of New York, Brooklyn |
| NCT01268462 | N/A | Jul 31, 2009 | Federal University of Pernambuco |
| NCT01784146 | N/A | Jun 30, 2009 | Federal University of Pernambuco |
| NCT00846014 | N/A | Jan 1, 2009 | University of Massachusetts |
| NCT00922350 | N/A | Jun 30, 2008 | Federal University of Pernambuco |
| NCT00788788 | Phase 1/Phase 2 (Phase 2) | Nov 1, 2007 | University of Witten/Herdecke |
| NCT00642447 | Phase 2/Phase 3 (Phase 3) | Apr 1, 2007 | Baqiyatallah Medical Sciences University |
| NCT00515606 | Phase 3 | Feb 1, 2007 | Baqiyatallah Medical Sciences University |
| NCT00315965 | Phase 1 | Jul 1, 2006 | University of Tuebingen |
| NCT00410150 | Phase 2 | Apr 1, 2006 | University of Cincinnati |
Organizations
Research & Development (22)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Federal University of Pernambuco | Academic/Hospital | 3 | 3 | 1 | 2008 |
| Air Liquide | For profit | 2 | 2 | 2 | 2009 |
| Baqiyatallah Medical Sciences University | Academic/Hospital | 2 | 2 | 1 | 2007 |
| University of Virginia | Academic/Hospital | 2 | 2 | 2 | 2013 |
| European Society for Paediatric Research | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Government of Canada | Government | 1 | 0 | 1 | 2005 |
| Mansoura University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| Northwell Health | Academic/Hospital | 1 | 1 | 1 | 2009 |
| People's Liberation Army of China | Government | 1 | 1 | 1 | 2012 |
| Poznan University | Academic/Hospital | 1 | 1 | 1 | 2017 |
| State University of New York, Brooklyn | Academic/Hospital | 1 | 0 | 1 | 2009 |
| Unity Health Toronto | Academic/Hospital | 1 | 1 | 1 | 2016 |
| University of Cincinnati | Academic/Hospital | 1 | 1 | 1 | 2006 |
| University of Hamburg | Academic/Hospital | 1 | 0 | 1 | 2009 |
| University of Lausanne | Academic/Hospital | 1 | 0 | 1 | 2010 |
| University of London | Academic/Hospital | 1 | 1 | 1 | 2012 |
| University of Louisville | Academic/Hospital | 1 | 1 | 1 | 2004 |
| University of Massachusetts | Academic/Hospital | 1 | 1 | 1 | 2009 |
| University of Nice Sophia Antipolis | Academic/Hospital | 1 | 1 | 1 | 2022 |
| University of Saskatchewan | Academic/Hospital | 1 | 1 | 1 | 2005 |
Marketing (24)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| A G L Welding Supply Co Inc | For profit | MKTG | Aug 18, 2019 |
| A G L Welding Supply Co Inc | For profit | NDA2 | Aug 18, 2019 |
| A-Ox Welding Supply Co, Inc. | For profit | NDA2 | Apr 23, 2018 |
| Air Liquide | For profit | NDA2 | Sep 7, 2013 |
| Air Products And Chemicals Inc | For profit | NDA2 | Jul 23, 2013 |
| Airgas Usa Llc | For profit | NDA2 | Jul 20, 2013 |
| BOC International | For profit | NDA2 | Mar 4, 2014 |
| General Air Service & Supply Company | For profit | MKTG | Jul 26, 2021 |
| General Air Service & Supply Company | For profit | NDA2 | Jul 26, 2021 |
| Ilmo Products Company | For profit | MKTG | Oct 27, 2019 |
| Ilmo Products Company | For profit | NDA2 | Oct 27, 2019 |
| Linde AG | For profit | NDA2 | Mar 4, 2014 |
| Matheson Tri-Gas Inc | For profit | MKTG | Oct 16, 2018 |
| Nexair | For profit | MKTG | Feb 20, 2016 |
| Nexair | For profit | NDA2 | Feb 20, 2016 |
| Norco | For profit | NDA2 | Jul 14, 2013 |
| Norco | For profit | NDA | Jul 14, 2013 |
| Praxair | For profit | NDA2 | Aug 5, 2013 |
| Praxair | For profit | SYN | Aug 5, 2013 |
| Praxair | For profit | SYN | Jul 21, 2013 |
| Roberts Pharmaceutical | For profit | MKTG | Jul 14, 2019 |
| Takeda | For profit | NDA2 | Jul 14, 2019 |
| Westair Gases & Equipment Inc | For profit | MKTG | Jun 27, 2020 |
| Westair Gases & Equipment Inc | For profit | NDA2 | Jun 27, 2020 |