tyrosinase
Tyrosinase is an oxidase that is the rate-limiting enzyme for controlling the production of melanin. The enzyme is mainly involved in two distinct reactions of melanin synthesis otherwise known as the Raper–Mason pathway. Firstly, the hydroxylation of a monophenol and secondly, the conversion of an o-diphenol to the corresponding o-quinone. o-Quinone undergoes several reactions to eventually form melanin. Tyrosinase is a copper-containing enzyme present in plant and animal tissues that catalyzes the production of melanin and other pigments from tyrosine by oxidation. It is found inside melanosomes which are synthesized in the skin melanocytes. In humans, the tyrosinase enzyme is encoded by the TYR gene. — Wikipedia
Clinical trial activity
2 trials · 3 clinical orgs · 0 marketing orgs
Earliest trial started Jun 1, 2002 (NCT00698100)
Timeline
Indications
Studied for
Mechanism of action
- TyrosinaseSupplementation
TYR supplementation
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTyrosinase ↗
- ChEMBLCHEMBL5095345 ↗
Also known as
- tyrosinase
- tyrosinase
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00153569 | Phase 2 | Mar 1, 2003 | Humboldt University |
| NCT00698100 | Phase 1 | Jun 1, 2002 | Cornell University, National Institutes of Health (NIH) |
Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Cornell University | Academic/Hospital | 1 | 1 | 1 | 2002 |
| Humboldt University | Academic/Hospital | 1 | 1 | 1 | 2003 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2002 |