5,10-methylene-5,6,7,8-tetrahydrofolate
Small moleculeexperimental
Clinical trial activity
3 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
3
Phase 3
0
Phase 4
0
Earliest trial started Apr 1, 2011 (NCT01397305)
Timeline
2010s
- Jan 1, 2011
Earliest Phase 1 Sponsor(trial)
Indications
Mechanism of action
- DNA polymerase nuINHIBITOR
POLN inhibitor
Chemistry & pharmacology
Oral
No
Parenteral
No
Topical
No
Also known as
- 5,10-methylene-5,6,7,8-tetrahydrofolate
- 5,10-methylenetetrahydrofolate
- 5,10-methylenetetrahydrofolate
- 5,10-methylenetetrahydrofolate
- 5,10-methylenetetrahydrofolate, (d-glu)-isomer
- 5,10-methylenetetrahydrofolate, (l-glu)-(s)-isomer
- 5,10-methylenetetrahydrofolate monohydrochloride, (l-glu)-isomer
- 5,10-methylenetetrahydrofolic acid
- ch2h4fol
- ch2h4folate
- n-(4-(3-amino-1,2,5,6,6a,7-hexahydro-1-oxoimidazo(1,5-f)pteridin-8(9h)-yl)benzoyl)-l-glutamic acid
- n5,n10-methylene-5,6,7,8-tetrahydrofolic acid
- tetrahydromethylenefolate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01987102 | Phase 1/Phase 2 (Phase 2) | Dec 1, 2013 | Isofol Medical AB |
| NCT01681472 | Phase 1/Phase 2 (Phase 2) | Sep 1, 2012 | Isofol Medical AB, University of Gothenburg |
| NCT01397305 | Phase 1/Phase 2 (Phase 2) | Apr 1, 2011 | Isofol Medical AB, University of Gothenburg |
Showing 3 of 3 trials
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Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Isofol Medical AB | For profit | 3 | 3 | 1 | 2011 |
| University of Gothenburg | Academic/Hospital | 2 | 0 | 1 | 2011 |
2 organizations
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