carboprost tromethamine
Trade name: hemabate
Approved
Jan 9, 1979
Carboprost is an analogue of naturally occurring prostaglandin F2alpha. Administered intramuscularly carboprost stimulates in the gravid uterus myometrial contractions similar to labor contractions at the end of a full term pregnancy. It is indicated for aborting pregnancy between the 13th and 20th weeks of gestation as calculated from the first day of the last normal menstrual period and for the treatment of postpartum hemorrhage due to uterine atony, which has not responded to conventional methods of management. The most frequent adverse reactions observed are related to its contractile effect on smooth muscle: vomiting, diarrhea, nausea, fever and flushing. Carboprost may augment the activity of other oxytocic agents. Concomitant use with other oxytocic agents is not recommended. — NCATS
Clinical trial activity
5 trials · 14 clinical orgs · 17 marketing orgs
Earliest trial started Jun 1, 2007 (NCT00989027)
Timeline
1970s
- Jan 9, 1979
Pharmacia & Upjohn — Earliest FDA Approval
- Jan 9, 1979
Pharmacia & Upjohn — NDA Secondary Org
- Jan 9, 1979
Pharmacia & Upjohn — NDA Organization
- Jan 9, 1979
Pfizer — Marketing Organization
- Jan 9, 1979
Pfizer — NDA Secondary Org
2010s
- Jul 2, 2019
Dr. Reddy's Laboratories — Marketing Organization
2020s
- Mar 25, 2021
Sunny Pharmtech Inc — Marketing Organization
- Jan 1, 2022
Earliest Phase 1 Sponsor(trial)
- Jan 27, 2022
Amneal Pharmaceuticals — Marketing Organization
- Aug 9, 2022
LONG GROVE PHARMS — Marketing Organization
- Feb 13, 2023
Caplin Point Laboratories — Marketing Organization
- May 19, 2023
Sola Pharms — Marketing Organization
- May 25, 2023
Eugia Pharma — Marketing Organization
- Jun 15, 2023
Alembic — Marketing Organization
- Jul 25, 2023
STERISCIENCE — Marketing Organization
- Jul 25, 2023
ONESOURCE SPECIALTY — Marketing Organization
- Aug 7, 2023
Gland Pharma Ltd — Marketing Organization
- Aug 7, 2023
Fosun — Marketing Organization
- Jan 25, 2024
Ani Pharmaceuticals — Marketing Organization
- Apr 3, 2024
Micro Labs Ltd India — Marketing Organization
- May 27, 2026
Somerset Pharmaceuticals — Marketing Organization
Indications
Mechanism of action
- Prostanoid FP receptorAGONIST
PTGFR agonist
Approval history
- approvedJan 9, 1979
Chemistry & pharmacology
SMILES
CCCCC[C@](C)(O)/C=C/[C@@H]1[C@@H](C/C=C\CCCC(=O)O)[C@@H](O)C[C@H]1O- Mol. weight
- 368.51 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Prescription Only
Oral
No
Parenteral
Yes
Topical
No
Sources
- ChEMBLCHEMBL1237122 ↗
- WikipediaCarboprost ↗
- NCATS7B5032XT6O ↗
- ChEMBLCHEMBL1237105 ↗
Also known as
- 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium (5z,9alpha,11beta,13e,15s)-9,11,15-trihydroxy-15-methylprosta-5,13-dien-1-oate
- 1,3-dihydroxy-2-(hydroxymethyl)propan-2-aminium (5z,9alpha,11beta,13e,15s)-9,11,15-trihydroxy-15-methylprosta-5,13-dien-1-oate
- 15-methylprostaglandin f2alpha-tromethamine
- (15s)-15-methyl-pgf2alpha tromethamine salt
- (15s)-15-methyl-pgf2alpha tromethamine salt
- 15(s)-15-methyl-pgf2alpha tromethamine salt
- 15(s)-15-methyl-pgf2alpha tromethamine salt
- (15s)-15-methylprostaglandin f2alpha tromethamine
- (15s)-15-methylprostaglandin f2alpha tromethamine
- 15(s)-15-methylprostaglandin f2alpha tromethamine
- 15(s)-15-methylprostaglandin f2alpha tromethamine
- carboprost
- carboprost
- carboprost
- carboprost
- carboprost
- carboprost
- carboprost
- carboprost
- carboprost
- carboprost trometamol
- carboprost trometamol
- carboprost trometamol
- carboprost trometamol
- carboprost trometanol
- carboprost trometanol
- carboprost tromethamine
- carboprost tromethamine
- carboprost tromethamine
- carboprost tromethamine
- carboprost tromethamine
- carboprost tromethamine
- carboprost tromethamine
- carboprost tromethamine
- hemabate
- hemabate
- hemabate
- hemabate
- methyldinoprost
- methyldinoprost
- prostin m-15
- u-32921
- u-32921
- u-32921e
- u-32921e
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06285409 | N/A | Apr 4, 2024 | Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, Canada |
| NCT05518812 | Early Phase 1 (Phase 1) | Jul 12, 2022 | Northwestern University |
| NCT02861482 | N/A | Jan 1, 2015 | Dongguan Maternity & Child Health Hospital, Guangzhou Medical University, Guangzhou University, Jiangmen Maternity & Child Health Care Hospital, Nanhai Maternity & Child Healthcare Hospital, Shenzhen University, Southern Medical University, Sun Yat-Sen University, The First Maternity & Child Healthcare Hospital of Huizhou, Xiaolan People's Hospital of Zhongshan, Zhongshan Dongsheng hospital |
| NCT01869556 | N/A | May 1, 2013 | Icahn School of Medicine at Mount Sinai |
| NCT00989027 | N/A | Jun 1, 2007 | Icahn School of Medicine at Mount Sinai |
Organizations
Research & Development (14)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Icahn School of Medicine at Mount Sinai | Academic/Hospital | 3 | 3 | 1 | 2007 |
| Dongguan Maternity & Child Health Hospital | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Guangzhou Medical University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Guangzhou University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Jiangmen Maternity & Child Health Care Hospital | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Mount Sinai Hospital, Canada | Academic/Hospital | 1 | 0 | 1 | 2024 |
| Nanhai Maternity & Child Healthcare Hospital | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Northwestern University | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Shenzhen University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Southern Medical University | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Sun Yat-Sen University | Academic/Hospital | 1 | 1 | 1 | 2015 |
| The First Maternity & Child Healthcare Hospital of Huizhou | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Xiaolan People's Hospital of Zhongshan | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Zhongshan Dongsheng hospital | Academic/Hospital | 1 | 0 | 1 | 2015 |
Marketing (23)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| Alembic | For profit | MKTG | Jun 15, 2023 |
| Amneal Pharmaceuticals | For profit | MKTG | Jan 27, 2022 |
| Ani Pharmaceuticals | For profit | MKTG | Jan 25, 2024 |
| Caplin Point Laboratories | For profit | MKTG | Feb 13, 2023 |
| Dr. Reddy's Laboratories | For profit | SYN | Jul 2, 2019 |
| Dr. Reddy's Laboratories | For profit | MKTG | Jul 2, 2019 |
| Eugia Pharma | For profit | MKTG | May 25, 2023 |
| Fosun | For profit | MKTG | Aug 7, 2023 |
| Gland Pharma Ltd | For profit | MKTG | Aug 7, 2023 |
| Gland Pharma Ltd | For profit | SYN | Aug 7, 2023 |
| LONG GROVE PHARMS | For profit | MKTG | Aug 9, 2022 |
| Micro Labs Ltd India | For profit | MKTG | Apr 3, 2024 |
| ONESOURCE SPECIALTY | For profit | MKTG | Jul 25, 2023 |
| Pfizer | For profit | MKTG | Jan 9, 1979 |
| Pfizer | For profit | NDA2 | Jan 9, 1979 |
| Pharmacia & Upjohn | For profit | NDA2 | Jan 9, 1979 |
| Pharmacia & Upjohn | For profit | NDA | Jan 9, 1979 |
| STERISCIENCE | For profit | MKTG | Jul 25, 2023 |
| STERISCIENCE | For profit | SYN | Jul 25, 2023 |
| Sola Pharms | For profit | MKTG | May 19, 2023 |
| Somerset Pharmaceuticals | For profit | MKTG | May 27, 2026 |
| Sunny Pharmtech Inc | For profit | MKTG | Mar 25, 2021 |
| Sunny Pharmtech Inc | For profit | MKTG | Mar 25, 2021 |