gsk2256294
Small moleculeexperimental
Clinical trial activity
5 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
4
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Jan 16, 2013 (NCT01762774)
Timeline
Indications
Studied for
- Brain Ischemia · Phase 1/Phase 2
- Diabetes Mellitus · Phase 2
- Endocrine System Diseases · Phase 2
- Endothelial Cells · Phase 1/Phase 2
- Glucose Metabolism Disorders · Phase 2
- Obesity · Phase 2
- Prediabetic State · Phase 2
- Pulmonary Disease, Chronic Obstructive · Phase 1
- Subarachnoid Hemorrhage · Phase 1/Phase 2
- Vasospasm, Intracranial · Phase 1/Phase 2
Mechanism of action
- Epoxide hydrataseINHIBITOR
EPHX2 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CNc1nc(C)nc(N[C@H]2CCC[C@@H](C(=O)NCc3ccc(C#N)cc3C(F)(F)F)C2)n1- Mol. weight
- 447.47 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3818875 ↗
Also known as
- gsk2256294
- gsk2256294
- gsk2256294
- n-((4-cyano-2-(trifluoromethyl)phenyl)methyl)-3-((4-methyl-6-(methylamino)-1,3,5-triazin-2-yl)amino)cyclohexanecarboxamide
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03486223 | Phase 2 | May 17, 2018 | National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), National Institutes of Health (NIH), Vanderbilt University |
| NCT03318783 | Phase 1/Phase 2 (Phase 2) | May 2, 2018 | Oregon Health and Science University |
| NCT02262689 | Phase 1 | Jan 8, 2015 | GlaxoSmithKline, Parexel |
| NCT02006537 | Phase 1 | Jan 31, 2014 | GlaxoSmithKline |
| NCT01762774 | Phase 1 | Jan 16, 2013 | GlaxoSmithKline |
Showing 5 of 5 trials
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Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| GlaxoSmithKline | For profit | 3 | 3 | 1 | 2013 |
| National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK) | Government | 1 | 0 | 1 | 2018 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2018 |
| Oregon Health and Science University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Parexel | For profit | 1 | 0 | 1 | 2015 |
| Vanderbilt University | Academic/Hospital | 1 | 1 | 1 | 2018 |
6 organizations
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