gdnf
Recombinant proteinexperimental
Glial cell line-derived neurotrophic factor (GDNF) is a protein that, in humans, is encoded by the GDNF gene. GDNF is a small protein that potently promotes the survival of many types of neurons. It signals through GFRα receptors, particularly GFRα1. It is also responsible for the determination of spermatogonia into primary spermatocytes, i.e. it is received by RET proto-oncogene (RET) and by forming gradient with SCF it divides the spermatogonia into two cells. As the result there is retention of spermatogonia and formation of spermatocyte. — Wikipedia
Clinical trial activity
2 trials · 2 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Jun 1, 2000 (NCT00005903)
Timeline
2000s
- Jan 1, 2000
Earliest Phase 2 Sponsor(trial)
Indications
Mechanism of action
- Glial cell line-derived neurotrophic factorSupplementation
GDNF supplementation
Chemistry & pharmacology
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaGlial cell line-derived neurotrophic factor ↗
- ChEMBLCHEMBL6068580 ↗
Also known as
- gdnf
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03652363 | Phase 2 | Oct 25, 2012 | University of Bristol |
| NCT00005903 | Phase 2 | Jun 1, 2000 | National Institute of Neurological Disorders and Stroke (NINDS) |
Showing 2 of 2 trials
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Organizations
Research & Development (2)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| National Institute of Neurological Disorders and Stroke (NINDS) | Government | 1 | 1 | 1 | 2000 |
| University of Bristol | Academic/Hospital | 1 | 1 | 1 | 2012 |
2 organizations
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