filanesib

Small moleculeexperimental

Filanesib is a kinesin spindle protein (KIF11) inhibitor which has recently been proposed as a cancer treatment, specifically for multiple myeloma. — Wikipedia

Clinical trial activity

8 trials · 5 clinical orgs · 0 marketing orgs

Phase 1
6
Phase 2
5
Phase 3
0
Phase 4
0

Earliest trial started Apr 1, 2007 (NCT00462358)

Timeline

2000s

  1. Jan 1, 2007

    Earliest Phase 1 Sponsor(trial)

2010s

  1. Jan 1, 2013

    Earliest Phase 2 Sponsor(trial)

Indications

Mechanism of action

Chemistry & pharmacology

Loading structure…

SMILES

CON(C)C(=O)N1N=C(c2cc(F)ccc2F)S[C@@]1(CCCN)c1ccccc1
Mol. weight
420.49 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • arry 520
  • arry-520
  • arry-520
  • arry-520
  • arry-520
  • filanesib
  • filanesib
  • filanesib

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT02384083Phase 1/Phase 2 (Phase 2)Sep 1, 2015Array BioPharma, Celgene, PETHEMA Foundation
NCT02092922Phase 2May 1, 2014Array BioPharma
NCT01989325Phase 2Nov 1, 2013Array BioPharma
NCT01372540Phase 1Feb 1, 2012Array BioPharma, Onyx, University of Texas at Houston
NCT01248923Phase 1Dec 1, 2010Array BioPharma
NCT00821249Phase 1/Phase 2 (Phase 2)Jan 1, 2009Array BioPharma
NCT00637052Phase 1/Phase 2 (Phase 2)Feb 1, 2008Array BioPharma
NCT00462358Phase 1Apr 1, 2007Array BioPharma
Showing 8 of 8 trials
Page 1 / 1

Organizations

Research & Development (5)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Array BioPharmaFor profit8622007
CelgeneFor profit1012015
OnyxFor profit1012012
PETHEMA FoundationAcademic/Hospital1112015
University of Texas at HoustonAcademic/Hospital1112012
5 organizations
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