xanthohumol
Small moleculeexperimental
Xanthohumol is a natural product found in the female inflorescences of Humulus lupulus, also known as hops. This compound is also found in beer and belongs to a class of compounds that contribute to the bitterness and flavor of hops. Xanthohumol is a prenylated chalconoid, biosynthesized by a type III polyketide synthase (PKS) and subsequent modifying enzymes. — Wikipedia
Clinical trial activity
11 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Mar 1, 2015 (NCT02432651)
Timeline
Indications
Mechanism of action
- UnclearUnclear
Unclear unclear
Chemistry & pharmacology
Loading structure…
SMILES
COc1cc(O)c(CC=C(C)C)c(O)c1C(=O)/C=C/c1ccc(O)cc1- Mol. weight
- 354.4 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaXanthohumol ↗
- ChEMBLCHEMBL253896 ↗
Also known as
- 1-(2,4-dihydroxy-6-methoxy-3-(3-methyl-2-butenyl)phenyl)-3-(4-hydroxyphenyl)-2-propen-1-one
- desmethylxanthohumol
- xanthohumol
- xanthohumol
- xanthohumol
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06745102 | N/A | Feb 1, 2024 | University of Vienna |
| NCT06286657 | N/A | Aug 1, 2023 | University of Vienna |
| NCT06225258 | Phase 2 | May 9, 2023 | Medical University of Lublin |
| NCT05711212 | N/A | Feb 15, 2023 | University of Bonn |
| NCT05524714 | N/A | Aug 1, 2022 | University of Bonn, University of Hohenheim |
| NCT06286644 | N/A | May 30, 2022 | University of Vienna |
| NCT05463393 | Early Phase 1 (Phase 1) | Oct 1, 2020 | Medical University of Lublin |
| NCT04590508 | Phase 2 | Oct 1, 2020 | National College of Natural Medicine, Oregon State University |
| NCT04847193 | N/A | Jun 13, 2019 | University of Vienna |
| NCT03735420 | Phase 1 | Jan 31, 2019 | National College of Natural Medicine, Oregon State University |
| NCT02432651 | Phase 1 | Mar 1, 2015 | Oregon State University |
Showing 11 of 11 trials
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Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Vienna | Academic/Hospital | 4 | 4 | 1 | 2019 |
| Oregon State University | Academic/Hospital | 3 | 1 | 2 | 2015 |
| Medical University of Lublin | Academic/Hospital | 2 | 2 | 2 | 2020 |
| National College of Natural Medicine | Academic/Hospital | 2 | 2 | 2 | 2019 |
| University of Bonn | Academic/Hospital | 2 | 2 | 1 | 2022 |
| University of Hohenheim | Academic/Hospital | 1 | 0 | 1 | 2022 |
6 organizations
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