CDEK
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etripamil

Small moleculeapproved

Approved

Dec 12, 2025

Clinical trial activity

10 trials · 10 clinical orgs · 1 marketing orgs

Phase 1
1
Phase 2
9
Phase 3
6
Phase 4
0

Earliest trial started Jan 1, 2015 (NCT02296190)

Timeline

2010s

  1. Jan 1, 2015

    Milestone Pharmaceuticals Inc. — Earliest Phase 2 Sponsor(trial)

  2. Jan 1, 2018

    Milestone Pharmaceuticals Inc. — Earliest Phase 3 Sponsor(trial)

2020s

  1. Jan 1, 2023

    Earliest Phase 1 Sponsor(trial)

  2. Dec 12, 2025

    Earliest FDA Approval

  3. Dec 12, 2025

    Milestone Pharmaceuticals Inc. — Marketing Organization

Indications

Approved for

Studied for

Mechanism of action

Approval history

  • approvedDec 12, 2025

Chemistry & pharmacology

Loading structure…

SMILES

COC(=O)c1cccc(CCN(C)CCC[C@@](C#N)(c2ccc(OC)c(OC)c2)C(C)C)c1
Mol. weight
452.6 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • etripamil
  • etripamil
  • etripamil
  • etripamil
  • (-)-msp-2017
  • (-)-msp-2017
  • msp-2017
  • msp-2017

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT06716021Phase 3Mar 31, 2025Cornell University, Milestone Pharmaceuticals Inc.
NCT05763953Phase 2Dec 11, 2023Milestone Pharmaceuticals Inc.
NCT05511870Phase 1Mar 31, 2023Fudan University, Ji Xing Pharmaceuticals (Shanghai) Co., Ltd., Milestone Pharmaceuticals Inc.
NCT05410860Phase 3Jun 30, 2022Capital Medical University, Ji Xing Pharmaceuticals (Shanghai) Co., Ltd., Milestone Pharmaceuticals Inc.
NCT04952610Phase 3Nov 30, 2021Milestone Pharmaceuticals Inc.
NCT04467905Phase 2Nov 19, 2020APCER Life Sciences, Milestone Pharmaceuticals Inc., The Montreal Health Innovations Coordinating Center, University of Montreal
NCT04072835Phase 3Sep 2, 2019IQVIA, Milestone Pharmaceuticals Inc.
NCT03635996Phase 3Aug 31, 2019Medpace, Inc., Milestone Pharmaceuticals Inc.
NCT03464019Phase 3Jun 18, 2018Medpace, Inc., Milestone Pharmaceuticals Inc.
NCT02296190Phase 2Jan 1, 2015Medpace, Inc., Milestone Pharmaceuticals Inc.
Showing 10 of 10 trials
Page 1 / 1

Organizations

Research & Development (10)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Milestone Pharmaceuticals Inc.For profit10832015
Medpace, Inc.For profit3022015
Ji Xing Pharmaceuticals (Shanghai) Co., Ltd.For profit2222022
APCER Life SciencesAcademic/Hospital1012020
Capital Medical UniversityAcademic/Hospital1012022
Cornell UniversityAcademic/Hospital1012025
Fudan UniversityAcademic/Hospital1012023
IQVIAFor profit1012019
The Montreal Health Innovations Coordinating CenterFor profit1012020
University of MontrealAcademic/Hospital1012020
10 organizations
Page 1 / 1

Marketing (1)

OrganizationOrg typeRelationshipDate
Milestone Pharmaceuticals Inc.For profitMKTGDec 12, 2025