canosimibe
Small moleculeexperimental
Clinical trial activity
5 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
5
Phase 3
4
Phase 4
0
Earliest trial started Feb 1, 2007 (NCT00440154)
Timeline
Indications
Studied for
Mechanism of action
- Acyl-coenzyme A thioesterase 1INHIBITOR
ACOT1 inhibitor
SOAT1 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
COc1ccc([C@@H]2[C@@H](CC[C@H](O)c3ccc(F)cc3)C(=O)N2c2ccc(CNC(=O)CCCCCCCCCCC(=O)NC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO)cc2)cc1- Mol. weight
- 809.97 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL6068542 ↗
Also known as
- ave5530
- ave5530
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00766688 | Phase 3 | Oct 1, 2008 | Sanofi |
| NCT00741715 | Phase 3 | Aug 1, 2008 | Radiant Research, Sanofi |
| NCT00718965 | Phase 3 | Jul 1, 2008 | Sanofi, Wake Forest University |
| NCT00729027 | Phase 3 | Jul 1, 2008 | Karolinska Institute, Sanofi |
| NCT00440154 | Phase 2 | Feb 1, 2007 | Sanofi |
Showing 5 of 5 trials
Page 1 / 1
Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Sanofi | For profit | 5 | 5 | 2 | 2007 |
| Karolinska Institute | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Radiant Research | Academic/Hospital | 1 | 0 | 1 | 2008 |
| Wake Forest University | Academic/Hospital | 1 | 0 | 1 | 2008 |
4 organizations
Page 1 / 1