ergonovine
Trade name: Ergotrate
Small moleculeexperimental
Ergonovine (also known as ergometrine) is the active water soluble component of ergot of rye. Ergonovine is being used as a maleate salt to prevent or treate postpartum haemorrhage and postabortion haemorrhage. Ergonovine stimulates alpha-adrenergic and serotonin receptors, thus activating contractions of uterine and vascular smooth muscle. Ergonovine may have depressant effect on CNS system as it binds to dopamine receptors. — NCATS
Clinical trial activity
12 trials · 15 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
4
Phase 3
4
Phase 4
4
Earliest trial started Nov 1, 2006 (NCT00499005)
Timeline
2010s
- Jan 1, 2013
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Mechanism of action
- UnclearUnclear
Unclear unclear
Chemistry & pharmacology
Loading structure…
SMILES
C[C@@H](CO)NC(=O)[C@@H]1C=C2c3cccc4[nH]cc(c34)C[C@H]2N(C)C1- Mol. weight
- 325.41 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL119443 ↗
- WikipediaErgometrine ↗
- NCATSWH41D8433D ↗
- ChEMBLCHEMBL1213135 ↗
Also known as
- (6ar,9r)-7-methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid ((s)-2-hydroxy-1-methyl-ethyl)-amide
- (6ar,9r)-7-methyl-4,6,6a,7,8,9-hexahydro-indolo[4,3-fg]quinoline-9-carboxylic acid ((s)-2-hydroxy-1-methyl-ethyl)-amide
- [8β(s)]-9,10-didehydro-n-(2-hydroxy-1-methylethyl)-6-methylergoline-8-carboxamide
- [8β(s)]-9,10-didehydro-n-(2-hydroxy-1-methylethyl)-6-methylergoline-8-carboxamide
- 9,10-didehydro-n-(2-hydroxy-1-methylethyl)-6-methylergoline-8β(s)-carboxamide
- 9,10-didehydro-n-(2-hydroxy-1-methylethyl)-6-methylergoline-8β(s)-carboxamide
- 9,10-didehydro-n-(α-(hydroxymethyl)ethyl)-6-methylergoline-8-β-carboxamide
- 9,10-didehydro-n-(α-(hydroxymethyl)ethyl)-6-methylergoline-8-β-carboxamide
- d-lysergic acid 1-hydroxymethylethylamide
- d-lysergic acid 1-hydroxymethylethylamide
- d-lysergic acid-l-propanolamide
- d-lysergic acid-l-propanolamide
- ergobasine
- ergobasine
- ergobasine
- ergometrin
- ergometrina
- ergometrina
- ergometrine
- ergometrine
- ergometrine
- ergometrine
- ergometrine
- ergometrine
- ergométrine
- ergométrine
- ergometrine maleate
- ergometrine maleate
- ergometrine maleate
- ergometrinum
- ergometrinum
- ergonovine
- ergonovine
- ergonovine
- ergonovine
- ergonovine
- ergonovine
- ergonovine
- ergonovine maleate
- ergonovine maleate
- ergonovine maleate
- ergonovine maleate
- ergonovine maleate
- ergonovine maleate
- ergostetrine
- ergotocine
- ergotocine
- ergotocine
- ergotrate
- ergotrate
- ergotrate maleate
- ergotrate maleate
- margonovine
- margonovine
- n-(2-hydroxy-1-methylethyl)-d-(+)-lysergamide
- n-(2-hydroxy-1-methylethyl)-d-(+)-lysergamide
- n-(α-(hydroxymethyl)ethyl)-d-lysergamide
- n-(α-(hydroxymethyl)ethyl)-d-lysergamide
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06285409 | N/A | Apr 4, 2024 | Icahn School of Medicine at Mount Sinai, Mount Sinai Hospital, Canada |
| NCT03693599 | Phase 4 | Oct 1, 2018 | Cairo University |
| NCT04300452 | Phase 4 | Apr 5, 2018 | University of Athens |
| NCT03578263 | N/A | Apr 1, 2018 | Aswan University |
| NCT02410759 | Phase 3 | Apr 1, 2015 | Cairo University |
| NCT02216383 | Phase 3 | Feb 1, 2015 | Ferring, Gloucestershire Hospitals NHS Foundation Trust, University of Bath, University of Bristol, University of the West of England |
| NCT02306733 | Phase 3 | Nov 1, 2014 | Cairo University |
| NCT01257243 | Phase 3 | Feb 1, 2013 | EMS S/A |
| NCT02044549 | Phase 4 | Jun 1, 2011 | Cairo University |
| NCT01689311 | N/A | Mar 1, 2009 | Canadian Anesthesiologists' Society, Icahn School of Medicine at Mount Sinai, University of Toronto |
| NCT00989027 | N/A | Jun 1, 2007 | Icahn School of Medicine at Mount Sinai |
| NCT00499005 | Phase 4 | Nov 1, 2006 | Government of Singapore, National University of Singapore |
Showing 12 of 12 trials
Page 1 / 1
Organizations
Research & Development (15)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Cairo University | Academic/Hospital | 4 | 4 | 2 | 2011 |
| Icahn School of Medicine at Mount Sinai | Academic/Hospital | 3 | 3 | 1 | 2007 |
| Aswan University | Academic/Hospital | 1 | 1 | 1 | 2018 |
| Canadian Anesthesiologists' Society | Academic/Hospital | 1 | 0 | 1 | 2009 |
| EMS S/A | For profit | 1 | 1 | 1 | 2013 |
| Ferring | For profit | 1 | 0 | 1 | 2015 |
| Gloucestershire Hospitals NHS Foundation Trust | Academic/Hospital | 1 | 0 | 1 | 2015 |
| Government of Singapore | Government | 1 | 0 | 1 | 2006 |
| Mount Sinai Hospital, Canada | Academic/Hospital | 1 | 0 | 1 | 2024 |
| National University of Singapore | Academic/Hospital | 1 | 1 | 1 | 2006 |
| University of Athens | Academic/Hospital | 1 | 1 | 1 | 2018 |
| University of Bath | Academic/Hospital | 1 | 0 | 1 | 2015 |
| University of Bristol | Academic/Hospital | 1 | 1 | 1 | 2015 |
| University of the West of England | Academic/Hospital | 1 | 0 | 1 | 2015 |
| University of Toronto | Academic/Hospital | 1 | 0 | 1 | 2009 |
15 organizations
Page 1 / 1