erdosteine
Small moleculeexperimental
Erdosteine is a molecule with mucolytic activity. Structurally it is a thioether derivative with two thioether groups. These two functional organosulfur groups contained in the molecule are released following first-pass metabolism with the conversion of erdosteine into its pharmacologically active metabolite Met-I (N-thiodiglycolyl-homocysteine). — Wikipedia
Clinical trial activity
5 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
2
Phase 3
1
Phase 4
2
Earliest trial started Mar 1, 2006 (NCT00338507)
Timeline
Indications
Approved for
Mechanism of action
- Unspecified targetOTHER
Anti-inflammatory, anti-oxidant
- Unspecified targetOTHER
Expectorant
- Unspecified targetAntioxidant
Antioxidant
Chemistry & pharmacology
Loading structure…
SMILES
O=C(O)CSCC(=O)NC1CCSC1=O- Mol. weight
- 249.31 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Racemic Mixture
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaErdosteine ↗
- ChEMBLCHEMBL1697744 ↗
Also known as
- dithiosteine
- dostein
- edirel
- erdosteine
- erdosteine
- erdosteine
- erdosteine
- erdosteine
- erdosteine
- erdosteine
- erdosteine
- esteclin
- rv 144
- rv-144
- s-(2-(n-3-(2-oxo-tetrahydrothienyl)acetamido))thioglycolic acid
- vectrine
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06038084 | Phase 4 | Apr 15, 2022 | Hanlim Pharm. Co., Ltd., Konkuk University |
| NCT02332044 | Phase 1 | Apr 1, 2014 | Daewoong Pharmaceutical Co. LTD. |
| NCT01176318 | Phase 4 | Aug 4, 2010 | Galen, University of Hull |
| NCT01032304 | Phase 3 | Aug 1, 2009 | Recipharm |
| NCT00338507 | Phase 2 | Mar 1, 2006 | Adams Respiratory Therapeutics |
Showing 5 of 5 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Adams Respiratory Therapeutics | For profit | 1 | 1 | 1 | 2006 |
| Daewoong Pharmaceutical Co. LTD. | For profit | 1 | 1 | 1 | 2014 |
| Galen | For profit | 1 | 0 | 1 | 2010 |
| Hanlim Pharm. Co., Ltd. | For profit | 1 | 0 | 1 | 2022 |
| Konkuk University | Academic/Hospital | 1 | 1 | 1 | 2022 |
| Recipharm | For profit | 1 | 1 | 1 | 2009 |
| University of Hull | Academic/Hospital | 1 | 1 | 1 | 2010 |
7 organizations
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