endothelin-3
Recombinant proteinexperimental
Endothelins are peptides with receptors and effects in many body organs. Endothelin constricts blood vessels and raises blood pressure. The endothelins are normally kept in balance by other mechanisms, but when overexpressed, they contribute to high blood pressure (hypertension), heart disease, and potentially other diseases. — Wikipedia
Clinical trial activity
4 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
1
Phase 3
0
Phase 4
0
Earliest trial started Jan 1, 2008 (NCT00406731)
Timeline
Indications
Mechanism of action
- Endothelin-3Supplementation
EDN3 supplementation
Chemistry & pharmacology
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaEndothelin ↗
Also known as
- endothelin-1
- endothelin-1
- endothelin-1
- endothelin 1 (human)
- endothelin 1 (human)
- endothelin 1 (pig)
- endothelin 1 (rat)
- endothelin-3
- endothelin (porcine)
- human endothelin
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT02906085 | N/A | Oct 1, 2016 | University of Copenhagen |
| NCT01100736 | Early Phase 1 (Phase 1) | Jan 1, 2009 | Encysive, University of Edinburgh |
| NCT00745693 | N/A | Mar 1, 2008 | Umea University, University of Edinburgh |
| NCT00406731 | Phase 2 | Jan 1, 2008 | University of Vienna |
Showing 4 of 4 trials
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Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Edinburgh | Academic/Hospital | 2 | 2 | 2 | 2008 |
| Encysive | For profit | 1 | 0 | 1 | 2009 |
| Umea University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| University of Copenhagen | Academic/Hospital | 1 | 1 | 1 | 2016 |
| University of Vienna | Academic/Hospital | 1 | 1 | 1 | 2008 |
5 organizations
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