bq 788
Small moleculeexperimental
Clinical trial activity
7 trials · 11 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
0
Phase 3
0
Phase 4
0
Earliest trial started May 1, 2003 (NCT00427232)
Timeline
2000s
- Jan 1, 2003
Earliest Phase 1 Sponsor(trial)
Indications
Mechanism of action
- Endothelin B receptor-like protein 2INHIBITOR
GPR37L1 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
CCCC[C@@H](NC(=O)[C@@H](Cc1cn(C(=O)OC)c2ccccc12)NC(=O)[C@H](CC(C)(C)C)NC(=O)N1[C@H](C)CCC[C@@H]1C)C(=O)O- Mol. weight
- 641.81 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL1741040 ↗
Also known as
- bq788
- bq788
- bq788
- bq 788
- bq-788
- bq-788
- bq-788
- n-2,6-dimethylpiperidinocarbonyl-gamma-meleu-trp(coome)-nle-ona
- n-cis-2,6-dimethylpiperidinocarbonyl-gamma-methylleucyl-tryptophyl(coome)-norleucine
- sodium 2-((2-(((2,6-dimethyl-1-piperidinyl)carbonyl)amino)-4,4-dimethylpentanoyl)(1-(methoxycarbonyl)-d-tryptophyl)amino)hexanoate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03679780 | Phase 1 | Oct 1, 2018 | University of Texas, Arlington |
| NCT04907838 | N/A | May 1, 2018 | University of Southern Denmark, University of Texas, Arlington |
| NCT02062346 | N/A | Aug 1, 2016 | British Heart Foundation, University of Edinburgh |
| NCT02086253 | N/A | Feb 1, 2014 | Rouen Normandy University |
| NCT02442466 | Early Phase 1 (Phase 1) | May 1, 2011 | California Institute of Technology, Katholieke Universiteit Leuven, MelCure SA, University of Bern |
| NCT00745693 | N/A | Mar 1, 2008 | Umea University, University of Edinburgh |
| NCT00427232 | Phase 1 | May 1, 2003 | University of Vienna |
Showing 7 of 7 trials
Page 1 / 1
Organizations
Research & Development (11)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Edinburgh | Academic/Hospital | 2 | 2 | 1 | 2008 |
| University of Texas, Arlington | Academic/Hospital | 2 | 1 | 2 | 2018 |
| British Heart Foundation | Academic/Hospital | 1 | 0 | 1 | 2016 |
| California Institute of Technology | Academic/Hospital | 1 | 0 | 1 | 2011 |
| Katholieke Universiteit Leuven | Academic/Hospital | 1 | 0 | 1 | 2011 |
| MelCure SA | For profit | 1 | 1 | 1 | 2011 |
| Rouen Normandy University | Academic/Hospital | 1 | 1 | 1 | 2014 |
| Umea University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| University of Bern | Academic/Hospital | 1 | 0 | 1 | 2011 |
| University of Southern Denmark | Academic/Hospital | 1 | 1 | 1 | 2018 |
| University of Vienna | Academic/Hospital | 1 | 1 | 1 | 2003 |
11 organizations
Page 1 / 1