elenbecestat
Small moleculeexperimental
Clinical trial activity
13 trials · 6 clinical orgs · 0 marketing orgs
Phase 1
10
Phase 2
3
Phase 3
2
Phase 4
0
Earliest trial started Dec 1, 2010 (NCT01294540)
Timeline
Indications
Mechanism of action
- Beta-secretase 1INHIBITOR
BACE1 inhibitor
Orally bioavailable small molecule BACE1 inhibitor, has shown robust lowering of cerebral amyloid-beta in preclinical and clinical studies
Chemistry & pharmacology
Loading structure…
SMILES
C[C@H]1OC[C@]2(c3cc(NC(=O)c4cnc(C(F)F)cn4)ccc3F)N=C(N)SC[C@H]12- Mol. weight
- 437.45 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3833309 ↗
- ChEMBLCHEMBL4204869 ↗
Also known as
- e2609
- e2609
- elenbecestat
- elenbecestat
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03055962 | Phase 1 | Feb 14, 2017 | Eisai |
| NCT03036280 | Phase 3 | Dec 1, 2016 | Biogen, Eisai |
| NCT02956486 | Phase 3 | Oct 1, 2016 | Biogen, Eisai |
| NCT02859207 | Phase 1 | Aug 1, 2016 | Eisai |
| NCT02322021 | Phase 2 | Nov 1, 2014 | Biogen, Eisai |
| NCT02222324 | Phase 1 | Aug 1, 2014 | Eisai |
| NCT02207790 | Phase 1 | Jul 1, 2014 | Eisai |
| NCT02055703 | Phase 1 | Jan 1, 2014 | Eisai |
| NCT01975636 | Phase 1 | Jun 1, 2013 | Eisai |
| NCT01716897 | Phase 1 | Oct 1, 2012 | California Clinical Trials, Eisai |
| NCT01600859 | Phase 1 | Jul 1, 2012 | California Clinical Trials, Eisai, Parexel |
| NCT01511783 | Phase 1 | Dec 1, 2011 | Compass Research, Eisai |
| NCT01294540 | Phase 1 | Dec 1, 2010 | Eisai, Loma Linda University |
Showing 13 of 13 trials
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Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Eisai | For profit | 13 | 13 | 3 | 2010 |
| Biogen | For profit | 3 | 0 | 2 | 2014 |
| California Clinical Trials | For profit | 2 | 0 | 1 | 2012 |
| Compass Research | For profit | 1 | 0 | 1 | 2011 |
| Loma Linda University | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Parexel | For profit | 1 | 0 | 1 | 2012 |
6 organizations
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