Ebastine
Trade name: kestine
Small moleculeexperimental
Ebastine is a H1 antihistamine with low potential for causing drowsiness. — Wikipedia
Clinical trial activity
4 trials · 4 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
0
Phase 3
0
Phase 4
3
Earliest trial started Oct 1, 2009 (NCT01144832)
Timeline
No events for the selected filters.
Indications
Approved for
Mechanism of action
- Histamine H1 receptorANTAGONIST
HRH1 antagonist
- Histamine H1 receptorINVERSE AGONIST
Histamine H1 receptor inverse agonist
Converted to carebastine which displays antihistamine activity and is likely responsible for most of the therapeutic activity.
Selective for H1 over H2 receptors. Potential activity against leukotriene C4 and platelet-activating factor but not against acetylcholine.
Chemistry & pharmacology
Loading structure…
SMILES
CC(C)(C)c1ccc(C(=O)CCCN2CCC(OC(c3ccccc3)c3ccccc3)CC2)cc1- Mol. weight
- 469.67 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaEbastine ↗
- ChEMBLCHEMBL305660 ↗
Also known as
- 4-diphenylmethoxy-1-(3-(4-tert-butylbenzoyl)propyl)piperidine
- bactil
- bastel
- busidril
- ebastel
- ebastel
- ebastin
- ebastine
- ebastine
- ebastine
- ebastine
- ebastine
- ebastine
- ebastine
- ebastine
- erostin
- evastel
- kestin
- kestine
- kestine
- kestine
- kestine
- las w-090
- las w-090
- las w-090
- rp-64305
- rp-64305
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01908465 | Phase 4 | Nov 1, 2013 | Katholieke Universiteit Leuven |
| NCT01940393 | Phase 4 | Aug 1, 2013 | Grupo de Alergología Clínica y Experimental, Universidad de Antioquia |
| NCT02065440 | N/A | Sep 1, 2011 | Seoul National University |
| NCT01144832 | Phase 4 | Oct 1, 2009 | Katholieke Universiteit Leuven |
Showing 4 of 4 trials
Page 1 / 1
Organizations
Research & Development (4)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Katholieke Universiteit Leuven | Academic/Hospital | 2 | 2 | 1 | 2009 |
| Grupo de Alergología Clínica y Experimental | Academic/Hospital | 1 | 1 | 1 | 2013 |
| Seoul National University | Academic/Hospital | 1 | 1 | 1 | 2011 |
| Universidad de Antioquia | Academic/Hospital | 1 | 0 | 1 | 2013 |
4 organizations
Page 1 / 1