succimer
Trade name: Chemet
Small moleculeapproved
Approved
May 18, 1982
Succimer, sold under the brand name Chemet among others, is a medication tool used to treat lead, mercury, and arsenic poisoning. When it's radiolabeled with technetium-99m, it's used in many types of diagnostic testing. — Wikipedia
Clinical trial activity
7 trials · 7 clinical orgs · 3 marketing orgs
Phase 1
2
Phase 2
5
Phase 3
1
Phase 4
0
Earliest trial started Jul 15, 1994 (NCT00342849)
Timeline
1980s
- May 18, 1982
Earliest FDA Approval
- May 18, 1982
General Electric — NDA Secondary Org
1990s
2020s
- Feb 18, 2022
Theragnostics Ltd — Marketing Organization
- Feb 18, 2022
Theragnostics Ltd — NDA Secondary Org
Indications
Approved for
Studied for
- Asperger Syndrome · Phase 2
- Autistic Disorder · Phase 2
- Child Development Disorders, Pervasive · Phase 2
- Hepatolenticular Degeneration · Early Phase 1
- Lead Poisoning · Phase 3
- Leukemia, Lymphocytic, Chronic, B-Cell · Phase 2
- Leukemia, Myelogenous, Chronic, BCR-ABL Positive · Phase 2
- Leukemia, Myeloid, Acute · Phase 2
- Leukemia, Myeloid, Chronic-Phase · Phase 2
- Myelodysplastic Syndromes · Phase 2
- Myeloproliferative Disorders · Phase 2
Mechanism of action
- Alpha-2-macroglobulinBINDING AGENT
Alpha-2-macroglobulin binding agent
- LeadCHELATING AGENT
Lead chelating agent
Approval history
- approvedMay 18, 1982
Chemistry & pharmacology
Loading structure…
SMILES
O=C(O)[C@@H](S)[C@@H](S)C(=O)O- Mol. weight
- 280.22 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
- Delivery
- Parenteral
- Availability
- Prescription Only
Oral
No
Parenteral
Yes
Topical
No
Sources
- ChEMBLCHEMBL2110572 ↗
- WikipediaSuccimer ↗
- ChEMBLCHEMBL1201073 ↗
- ChEMBLCHEMBL1200797 ↗
- WikipediaDimercaptosuccinic acid ↗
Also known as
- 2,3-dimercaptosuccinic acid
- 2,3-dimercaptosuccinic acid
- chemet
- chemet
- chemet
- dimercaptosuccinic acid
- dimercaptosuccinic acid
- dimercaptosuccinic acid
- dimercaptosuccinic acid
- dim-sa
- dim-sa
- dmsa
- dmsa
- dmsa
- dmsa
- dmsa kidney reagent
- dmsa kidney reagent
- meso-2,3-dimercaptobernsteinsäure
- meso-2,3-dimercaptobernsteinsäure
- meso-2,3-dimercaptosuccinic acid
- meso-2,3-dimercaptosuccinic acid
- meso-2,3-dimercaptosuccinic acid
- meso-dimercaptosuccinic acid
- meso-dimercaptosuccinic acid
- meso-dimercaptosuccinic acid
- mpi dmsa kidney reagent
- mpi dmsa kidney reagent
- mpi dmsa kidney reagent
- succimer
- succimer
- succimer
- succimer
- succimer
- succimer
- succimer
- succimer
- succimer
- succimer
- succimer
- technetium (99mtc) dimercaptosuccinic acid for injection
- technetium (99mtc) succimer
- technetium succimer
- technetium succimer
- technetium tc 99m succimer
- technetium tc 99m succimer
- technetium tc-99m succimer
- technetium tc-99m succimer
- technetium tc-99m succimer kit
- technetium tc-99m succimer kit
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06811233 | Phase 2 | May 8, 2025 | University of Texas at Houston |
| NCT03957720 | Early Phase 1 (Phase 1) | Mar 15, 2019 | Zhejiang University |
| NCT03630991 | Phase 2 | Oct 31, 2018 | University of Texas at Houston |
| NCT00376194 | Phase 2 | Sep 1, 2006 | National Institute of Mental Health (NIMH) |
| NCT00811083 | Phase 1/Phase 2 (Phase 2) | May 1, 2005 | Southwest College of Naturopathic Medicine |
| NCT00004838 | N/A | Sep 1, 1997 | National Institutes of Health (NIH), Ohio State University |
| NCT00342849 | Phase 3 | Jul 15, 1994 | National Institute of Environmental Health Sciences (NIEHS) |
Showing 7 of 7 trials
Page 1 / 1
Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Texas at Houston | Academic/Hospital | 2 | 2 | 1 | 2018 |
| National Institute of Environmental Health Sciences (NIEHS) | Government | 1 | 1 | 1 | 1994 |
| National Institute of Mental Health (NIMH) | Government | 1 | 1 | 1 | 2006 |
| National Institutes of Health (NIH) | Government | 1 | 1 | 1 | 1997 |
| Ohio State University | Academic/Hospital | 1 | 0 | 1 | 1997 |
| Southwest College of Naturopathic Medicine | Academic/Hospital | 1 | 1 | 1 | 2005 |
| Zhejiang University | Academic/Hospital | 1 | 1 | 1 | 2019 |
7 organizations
Page 1 / 1
Marketing (5)
| Organization | Org type | Relationship | Date |
|---|---|---|---|
| General Electric | For profit | NDA2 | May 18, 1982 |
| Recordati | For profit | NDA2 | Jan 30, 1991 |
| Recordati | For profit | NDA | Jan 30, 1991 |
| Theragnostics Ltd | For profit | MKTG | Feb 18, 2022 |
| Theragnostics Ltd | For profit | NDA2 | Feb 18, 2022 |