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dapoxetine

Trade name: priligy

Small moleculeexperimental

Dapoxetine, sold under the brand name Priligy among others, is a selective serotonin reuptake inhibitor (SSRI) used for the treatment of premature ejaculation (PE) in men ages 18 to 64 years old. Dapoxetine works by inhibiting the serotonin transporter, increasing serotonin's action at the postsynaptic cleft, and as a consequence promoting ejaculatory delay. As a member of the SSRI family, dapoxetine was initially created as an antidepressant. However, unlike other SSRIs, dapoxetine is absorbed and eliminated rapidly in the body. Its fast-acting property makes it suitable for the treatment of PE, but not as an antidepressant. — Wikipedia

Clinical trial activity

24 trials · 21 clinical orgs · 0 marketing orgs

Phase 1
6
Phase 2
15
Phase 3
13
Phase 4
2

Earliest trial started Jun 1, 2003 (NCT00211107)

Timeline

2000s

  1. Jan 1, 2003

    Earliest Phase 3 Sponsor(trial)

2010s

  1. Jan 1, 2011

    Earliest Phase 1 Sponsor(trial)

2020s

  1. Jan 1, 2022

    Earliest Phase 2 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • Serotonin transporterINHIBITOR

    SLC6A4 inhibitor

    Dapoxetine is a selective serotonin reuptake inhibitor (SSRI). It blocks axonal re-uptake of serotonin (5-HT) from the synapse by 5-HT transporters, resulting in enhanced 5-HT neurotransmission, stimulation of post-synaptic membrane 5-HT2C receptors and ejaculatory delay.

    Dapoxetine is a potent selective serotonin reuptake inhibitor (SSRI) (pKi = 8 nM). Equilibrium radioligand binding studies using human cells demonstrate that dapoxetine binds to serotonin (5-HT), norepinephrine (NE) and dopamine (DA) reuptake transporters and inhibits uptake in the following order of potency: NE<5-HT>>DA.

Chemistry & pharmacology

Loading structure…

SMILES

CN(C)[C@@H](CCOc1cccc2ccccc12)c1ccccc1
Mol. weight
305.42 g/mol
Lipinski Ro5
Pass
Rule of 3
No
Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • dapoxetina
  • dapoxetina
  • dapoxetine
  • dapoxetine
  • dapoxetine
  • dapoxetine
  • dapoxetine
  • dapoxetine
  • dapoxetine
  • dapoxetine
  • dapoxetine hcl
  • dapoxetine hcl
  • dapoxetine hydrochloride
  • dapoxetine hydrochloride
  • dapoxetine hydrochloride
  • dapoxetine hydrochloride
  • dapoxetine hydrochloride
  • dapoxetinum
  • dapoxetinum
  • ly 210448
  • ly-210448
  • ly-210448
  • n,n-dimethyl-alpha-(2-(1-naphthalenyloxy)ethyl)benzenemethanamine
  • priligy
  • priligy
  • priligy
  • priligy

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07081659Phase 2/Phase 3 (Phase 3)Mar 1, 2024Benha University
NCT05556083Phase 2Oct 1, 2022Al Azhar University
NCT06425224Phase 3Jun 15, 2022Boston Medical Group
NCT04850703Phase 1/Phase 2 (Phase 2)Feb 2, 2021Hereford Hospital, Sexual Salud Valclinic, Spanish Foundation for Neurometrics Development
NCT04361305Phase 3Jun 3, 2020Jiao Tong University
NCT04703127Phase 3Mar 30, 2020Sohag University
NCT04085354Phase 3Feb 10, 2019Sohag University
NCT03583112N/AJul 10, 2018The Northwest Women's and Children's Hospital, Xidian University
NCT03177746Phase 4Jul 3, 2017NeuTec Pharma
NCT02939495Phase 4Oct 1, 2016Bagcilar Research and Training Hospital, NeuTec Pharma
NCT02844998N/AJan 1, 2015University of Ankara
NCT02485041Phase 1Nov 1, 2014Chonbuk National University, SK Chemicals
NCT02485028Phase 1Oct 1, 2013SK Chemicals, Sungkyunkwan University
NCT01928563Phase 1Sep 1, 2013Dong-A Pharmaceutical, University of Ulsan
NCT01366664Phase 1Apr 1, 2011Johnson and Johnson
NCT01419470Phase 1/Phase 2 (Phase 2)Feb 1, 2011Yuhan Pharmaceutical Company
NCT01230762Phase 3Oct 28, 2010Alza
NCT01063881Phase 3May 1, 2010Johnson and Johnson
NCT01063855Phase 3Apr 1, 2010Johnson and Johnson
NCT00211094Phase 3Sep 15, 2005Alza
Showing 20 of 24 trials
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Organizations

Research & Development (21)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Johnson and JohnsonFor profit6622004
AlzaFor profit3312003
NeuTec PharmaFor profit2212016
SK ChemicalsFor profit2212013
Sohag UniversityAcademic/Hospital2212019
Al Azhar UniversityAcademic/Hospital1112022
Bagcilar Research and Training HospitalAcademic/Hospital1012016
Benha UniversityAcademic/Hospital1112024
Boston Medical GroupAcademic/Hospital1112022
Chonbuk National UniversityAcademic/Hospital1012014
Dong-A PharmaceuticalFor profit1112013
Hereford HospitalAcademic/Hospital1012021
Jiao Tong UniversityAcademic/Hospital1112020
Sexual Salud ValclinicAcademic/Hospital1012021
Spanish Foundation for Neurometrics DevelopmentAcademic/Hospital1112021
Sungkyunkwan UniversityAcademic/Hospital1012013
The Northwest Women's and Children's HospitalAcademic/Hospital1012018
University of AnkaraAcademic/Hospital1112015
University of UlsanAcademic/Hospital1012013
Xidian UniversityAcademic/Hospital1112018
21 organizations
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