tagatose
Tagatose is a hexose monosaccharide. It is found in small quantities in a variety of foods, and has attracted attention as an alternative sweetener. It is often found in dairy products, because it is formed when milk is heated. It is similar in texture and appearance to sucrose :215 and is 92% as sweet,:198 but with only 38% of the calories.:209 Tagatose is generally recognized as safe by the Food and Agriculture Organization and the World Health Organization, and has been since 2001. Since it is metabolized differently from sucrose, tagatose has a minimal effect on blood glucose and insulin levels. Tagatose is also approved as a tooth-friendly ingredient for dental products. Consumption of more than about 30 grams of tagatose in a dose may cause gastric disturbance in some people, as it is mostly processed in the large intestine, similar to soluble fiber.:214 — Wikipedia
Clinical trial activity
4 trials · 6 clinical orgs · 0 marketing orgs
Earliest trial started Apr 1, 2007 (NCT00955747)
Timeline
Indications
Studied for
Mechanism of action
- Unspecified targetUnclear
Unclear
Chemistry & pharmacology
SMILES
O=C(CO)[C@@H](O)[C@@H](O)[C@H](O)CO- Mol. weight
- 180.16 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaTagatose ↗
- ChEMBLCHEMBL1236183 ↗
Also known as
- d-lyxo-hex-2-ulose
- d-lyxo-hex-2-ulose
- d-lyxo-hexulose
- d-lyxo-hexulose
- d-tag
- d-tag
- d-tagatose
- d-tagatose
- d-tagatose
- d-tagatose
- tagatose
- tagatose
- tagatose
- tagatose
- tagatose, (alpha-d)-isomer
- tagatose, (beta-d)-isomer
- tagatose, (d)-isomer
- tagatose, (dl)-isomer
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT06230900 | N/A | Feb 5, 2024 | Gelderse Vallei Hospital, TNO, Wageningen University |
| NCT04327245 | N/A | Jan 15, 2017 | University of Chile |
| NCT00961662 | Phase 2 | Feb 1, 2008 | Spherix Incorporated, University of Kentucky |
| NCT00955747 | Phase 3 | Apr 1, 2007 | Spherix Incorporated, University of Kentucky |
Organizations
Research & Development (6)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Spherix Incorporated | For profit | 2 | 2 | 2 | 2007 |
| University of Kentucky | Academic/Hospital | 2 | 0 | 2 | 2007 |
| Gelderse Vallei Hospital | Academic/Hospital | 1 | 0 | 1 | 2024 |
| TNO | For profit | 1 | 0 | 1 | 2024 |
| University of Chile | Academic/Hospital | 1 | 1 | 1 | 2017 |
| Wageningen University | Academic/Hospital | 1 | 1 | 1 | 2024 |