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d-serine

Small moleculeexperimental

Serine (symbol Ser or S) is an α-amino acid that is used in the biosynthesis of proteins. It contains an α-amino group, a carboxyl group, and a side chain consisting of a hydroxymethyl group, classifying it as a polar amino acid. It can be synthesized in the human body under normal physiological circumstances, making it a nonessential amino acid. It is encoded by the codons UCU, UCC, UCA, UCG, AGU and AGC. — Wikipedia

Clinical trial activity

27 trials · 22 clinical orgs · 0 marketing orgs

Phase 1
6
Phase 2
18
Phase 3
4
Phase 4
2

Earliest trial started Sep 1, 2002 (NCT00237809)

Timeline

2000s

  1. Jan 1, 2002

    Earliest Phase 3 Sponsor(trial)

  2. Jan 1, 2003

    Earliest Phase 2 Sponsor(trial)

  3. Jan 1, 2005

    Earliest Phase 1 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • d serine
  • d serine
  • d-serine
  • d-serine
  • d-serine

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07312110Phase 2Dec 31, 2025University of Bergen
NCT07263022Phase 3Dec 1, 2025National Institute of Mental Health (NIMH), University of Minnesota
NCT07079930Phase 1Nov 30, 2025Hebrew University
NCT06876129Phase 1Apr 1, 2025Mclean Hospital
NCT05046353Phase 1/Phase 2 (Phase 2)Jan 1, 2022Columbia University, National Institute of Mental Health (NIMH), New York University
NCT04140773N/ANov 25, 2021University of Basel
NCT04721249N/AJul 1, 2021University of Basel
NCT03711500Phase 1/Phase 2 (Phase 2)Mar 13, 2019Columbia University, New York University
NCT03778320Phase 1Dec 14, 2018Concert Pharmaceuticals
NCT02156908Phase 2Aug 1, 2014New York University
NCT01715051Phase 2Feb 1, 2014University of Cincinnati
NCT01804920Phase 2/Phase 3 (Phase 3)Jan 1, 2013Herzog Hospital
NCT01474395Phase 2Mar 1, 2012Columbia University, New York University
NCT01459029Phase 2Nov 1, 2011Hebrew University, Herzog Hospital
NCT01018056Phase 4Nov 1, 2009Johns Hopkins University, National Institute of Mental Health (NIMH)
NCT00817336Phase 2Jun 1, 2009New York University
NCT00826202Phase 2Mar 1, 2009National Institute of Mental Health (NIMH), New York University, The Zucker Hillside Hospital, Yale University
NCT00816894Phase 2Jan 1, 2009Herzog Hospital, Israel Science Foundation
NCT02051426N/AApr 30, 2007Herzog Hospital
NCT00322023Phase 2Mar 1, 2006National Institute of Mental Health (NIMH), New York University
Showing 20 of 27 trials
Page 1 / 2

Organizations

Research & Development (22)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Herzog HospitalAcademic/Hospital7642003
New York UniversityAcademic/Hospital7412006
Hebrew UniversityAcademic/Hospital5232003
National Institute of Mental Health (NIMH)Government5132006
Columbia UniversityAcademic/Hospital3212012
Yale UniversityAcademic/Hospital3222002
Donaghue FoundationAcademic/Hospital2012002
Stanley Medical Research InstituteAcademic/Hospital2022004
University of BaselAcademic/Hospital2212021
Brain & Behavior Research FoundationAcademic/Hospital1012002
China Medical UniversityAcademic/Hospital1112005
Concert PharmaceuticalsFor profit1112018
Department of Veteran AffairsGovernment1012005
Government of TaiwanGovernment1012005
Israel Science FoundationAcademic/Hospital1012009
Johns Hopkins UniversityAcademic/Hospital1112009
Mclean HospitalAcademic/Hospital1112025
Tel Aviv UniversityAcademic/Hospital1112004
The Zucker Hillside HospitalAcademic/Hospital1012009
University of BergenAcademic/Hospital1112025
22 organizations
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