lapaquistat
Small moleculeexperimental
Clinical trial activity
16 trials · 1 clinical orgs · 0 marketing orgs
Phase 1
0
Phase 2
16
Phase 3
13
Phase 4
0
Earliest trial started Sep 1, 2004 (NCT00864643)
Timeline
Indications
Mechanism of action
- Squalene synthetaseINHIBITOR
FDFT1 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
COc1cccc([C@H]2O[C@H](CC(=O)N3CCC(CC(=O)O)CC3)C(=O)N(CC(C)(C)COC(C)=O)c3ccc(Cl)cc32)c1OC- Mol. weight
- 645.15 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL435224 ↗
Also known as
- 1-((1-(3-acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3-yl)acetyl)piperidine-4-acetic acid
- (1-(2-(1-(2-carboxyoxy-1,1-dimethylethyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo(e)(1,4)oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid
- lapaquistat
- lapaquistat
- lapaquistat
- lapaquistat acetate
- lapaquistat acetate
- lapaquistat acetate
- tak475
- tak 475
- tak-475
- tak-475
- tak-475
- tak-475
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00532558 | Phase 3 | Oct 1, 2007 | Takeda |
| NCT00865228 | Phase 2 | Jul 1, 2007 | Takeda |
| NCT00532311 | Phase 3 | Jul 1, 2007 | Takeda |
| NCT00286481 | Phase 3 | Mar 1, 2006 | Takeda |
| NCT00813527 | Phase 2 | Feb 1, 2006 | Takeda |
| NCT00868127 | Phase 3 | Dec 1, 2005 | Takeda |
| NCT00249899 | Phase 3 | Nov 1, 2005 | Takeda |
| NCT00263081 | Phase 3 | Nov 1, 2005 | Takeda |
| NCT00256178 | Phase 3 | Oct 1, 2005 | Takeda |
| NCT00251680 | Phase 3 | Oct 1, 2005 | Takeda |
| NCT00249912 | Phase 3 | Oct 1, 2005 | Takeda |
| NCT00268697 | Phase 3 | Oct 1, 2005 | Takeda |
| NCT00143663 | Phase 3 | Sep 1, 2005 | Takeda |
| NCT00143676 | Phase 3 | Aug 1, 2005 | Takeda |
| NCT00487994 | Phase 3 | Nov 1, 2004 | Takeda |
| NCT00864643 | Phase 2 | Sep 1, 2004 | Takeda |
Showing 16 of 16 trials
Page 1 / 1
Organizations
Research & Development (1)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Takeda | For profit | 16 | 16 | 2 | 2004 |
1 organizations
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