d-ribose

Small moleculeexperimental

Ribose is a simple sugar and carbohydrate with molecular formula C5H10O5 and the linear-form composition H−(C=O)−(CHOH)4−H. The naturally occurring form, d-ribose, is a component of the ribonucleotides from which RNA is built, and so this compound is necessary for coding, decoding, regulation and expression of genes. It has a structural analog, deoxyribose, which is a similarly essential component of DNA. l-ribose is an unnatural sugar that was first prepared by Emil Fischer and Oscar Piloty in 1891. It was not until 1909 that Phoebus Levene and Walter Jacobs recognised that d-ribose was a natural product, the enantiomer of Fischer and Piloty's product, and an essential component of nucleic acids. Fischer chose the name "ribose" as it is a partial rearrangement of the name of another sugar, arabinose, of which ribose is an epimer at the 2' carbon; both names also relate to gum arabic, from which arabinose was first isolated and from which they prepared l-ribose. — Wikipedia

Clinical trial activity

11 trials · 22 clinical orgs · 0 marketing orgs

Phase 1
0
Phase 2
5
Phase 3
0
Phase 4
0

Earliest trial started Mar 1, 1995 (NCT00004658)

Timeline

1990s

  1. Jan 1, 1995

    Earliest Phase 2 Sponsor(trial)

Indications

Mechanism of action

  • Unspecified targetSupplementation

    supplementation

Chemistry & pharmacology

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • d-ribose
  • d-ribose
  • ribose
  • ribose

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT03133793Phase 2Nov 1, 2017University of Kansas
NCT03411369N/AJun 1, 2016University of Pavia
NCT02260141Phase 2Sep 1, 2014Practitioners Alliance Network
NCT01858480Phase 2Jul 1, 2013Boston University, RiboCor, Inc.
NCT01727479N/AAug 31, 2012Atrium Innovations, Laval University
NCT01315210Phase 2May 1, 2011RiboCor, Inc., University of Kentucky
NCT01108549N/AApr 1, 2009Bioenergy Life Science, Inc., Integrative Therapeutics, Inc., Kona Research Center
NCT00821067N/AJan 1, 2009Bioenergy Life Science, Inc.
NCT00566514N/AJul 1, 2006Bioenergy Life Science, Inc., The Annapolis Center for Effective CFS/Fibromyalgia Therapies
NCT00329485N/AJun 1, 2006Department of Veteran Affairs, Maine Research Associates, Ohio State University, Scottsdale Cardiovascular Research Institute, Texas Heart Institute, University of Florida, University of Utah, Valen Labs
NCT00004658Phase 2Mar 1, 1995National Center for Research Resources (NCRR), University of California, San Diego
Showing 11 of 11 trials
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Organizations

Research & Development (22)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Bioenergy Life Science, Inc.For profit3212006
RiboCor, Inc.For profit2212011
Atrium InnovationsFor profit1012012
Boston UniversityAcademic/Hospital1012013
Department of Veteran AffairsGovernment1012006
Integrative Therapeutics, Inc.For profit1012009
Kona Research CenterAcademic/Hospital1112009
Laval UniversityAcademic/Hospital1112012
Maine Research AssociatesAcademic/Hospital1012006
National Center for Research Resources (NCRR)Government1111995
Ohio State UniversityAcademic/Hospital1012006
Practitioners Alliance NetworkAcademic/Hospital1112014
Scottsdale Cardiovascular Research InstituteAcademic/Hospital1012006
Texas Heart InstituteAcademic/Hospital1012006
The Annapolis Center for Effective CFS/Fibromyalgia TherapiesAcademic/Hospital1012006
University of California, San DiegoAcademic/Hospital1011995
University of FloridaAcademic/Hospital1012006
University of KansasAcademic/Hospital1112017
University of KentuckyAcademic/Hospital1012011
University of PaviaAcademic/Hospital1112016
22 organizations
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