pranlukast
Trade name: Onon
Small moleculeexperimental
Pranlukast is a cysteinyl leukotriene receptor-1 antagonist. This drug works similarly to Merck & Co.'s montelukast (Singulair). It is widely used in Japan. — Wikipedia
Clinical trial activity
4 trials · 12 clinical orgs · 0 marketing orgs
Phase 1
1
Phase 2
3
Phase 3
3
Phase 4
0
Earliest trial started Nov 1, 2004 (NCT00127647)
Timeline
Indications
Mechanism of action
- Cysteinyl leukotriene receptor 1ANTAGONIST
Cysteinyl leukotriene receptor 1 antagonist
Selective for CysLT1R over CysLT2R.
- Cysteinyl leukotriene receptorINHIBITOR
Cysteinyl leukotriene receptor inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
O=C(Nc1cccc2c(=O)cc(-c3nnn[nH]3)oc12)c1ccc(OCCCCc2ccccc2)cc1- Mol. weight
- 481.51 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
- Delivery
- Oral
Oral
Yes
Parenteral
No
Topical
No
Sources
- WikipediaPranlukast ↗
- ChEMBLCHEMBL21333 ↗
Also known as
- 8-(4 (4-phenylbutoxy)benzoyl)amino-2-(tetrazol-5'-yl)-4-oxo-4h-1-benzopyran
- azlaire
- ono 1078
- ono 1078
- ono 1078
- ono 1078
- ono 1078
- ono 1078
- ono-1078
- ono-1078
- ono-1078
- ono-1078
- onon
- ono-rs 411
- ono-rs 411
- ono-rs 411
- ono-rs-411
- pranlukast
- pranlukast
- pranlukast
- pranlukast
- pranlukast
- pranlukast
- pranlukast
- pranlukast
- pranlukast hydrate
- pranlukast hydrate
- pranlukast hydrate
- sb 205312
- sb-205312
- sb-205312
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT03826485 | Phase 1 | Apr 1, 2019 | SamA Pharmaceutical Co., Ltd |
| NCT01539304 | Phase 3 | Sep 1, 2010 | Catholic University of Korea, Hanyang University, Inha University, Kyung Hee University, SamA Pharmaceutical Co., Ltd, Seoul National University, Soonchunhyang University, Sungkyunkwan University, University of Ulsan, Yonsei University |
| NCT00410735 | Phase 3 | Dec 1, 2006 | Ono Pharmaceuticals |
| NCT00127647 | Phase 3 | Nov 1, 2004 | Merck |
Showing 4 of 4 trials
Page 1 / 1
Organizations
Research & Development (12)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| SamA Pharmaceutical Co., Ltd | For profit | 2 | 2 | 2 | 2010 |
| Catholic University of Korea | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Hanyang University | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Inha University | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Kyung Hee University | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Merck | For profit | 1 | 1 | 1 | 2004 |
| Ono Pharmaceuticals | For profit | 1 | 1 | 1 | 2006 |
| Seoul National University | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Soonchunhyang University | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Sungkyunkwan University | Academic/Hospital | 1 | 0 | 1 | 2010 |
| University of Ulsan | Academic/Hospital | 1 | 0 | 1 | 2010 |
| Yonsei University | Academic/Hospital | 1 | 0 | 1 | 2010 |
12 organizations
Page 1 / 1