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cocoa bean

Botanicalexperimental

The cocoa bean, also known as cocoa or cacao, is the dried and fully fermented seed of Theobroma cacao, the cacao tree, from which cocoa solids and cocoa butter can be extracted. Cacao trees are native to the Amazon rainforest. They are the basis of chocolate and Mesoamerican foods including tejate, an indigenous Mexican drink. — Wikipedia

Clinical trial activity

79 trials · 83 clinical orgs · 0 marketing orgs

Phase 1
4
Phase 2
4
Phase 3
2
Phase 4
2

Earliest trial started Apr 1, 2005 (NCT00511420)

Timeline

2000s

  1. Jan 1, 2005

    Earliest Phase 3 Sponsor(trial)

  2. Jan 1, 2007

    Earliest Phase 1 Sponsor(trial)

  3. Jan 1, 2008

    Earliest Phase 2 Sponsor(trial)

Indications

Approved for

Studied for

Mechanism of action

  • Unspecified targetAntioxidant

    antioxidant

Chemistry & pharmacology

Chirality
Single Stereoisomer
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • chocolate
  • chocolate
  • chocolate
  • chocolate
  • cocoa
  • cocoa
  • cocoa
  • cocoa
  • cocoa bean
  • cocoa powder

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT07308093N/ADec 15, 2025Lahore University of Biological and Applied Sciences
NCT07272551N/AJul 19, 2025Istanbul Medipol University
NCT07093346N/AJun 10, 2025University of Nottingham
NCT06965179N/AApr 16, 2025Mersin University
NCT06565507Phase 2/Phase 3 (Phase 3)Dec 15, 2024Cayetano Heredia University, Oxfendazole Development Group
NCT06509191N/ASep 30, 2024Sultan Qaboos University
NCT06529458N/AAug 29, 2024Kayseri City Hospital
NCT06446427N/AJun 1, 2024University of Bern
NCT06295900N/AJan 5, 2024Nigde Omer Halisdemir University
NCT06769035N/AAug 20, 2023University of Guadalajara
NCT06507163N/AMay 3, 2023Erciyes University
NCT05545865N/ASep 1, 2022University of California, Davis
NCT05335304N/AApr 18, 2022Muğla Sıtkı Koçman University
NCT05528575N/AJan 1, 2022Department of Defense, University of Reading
NCT05247034N/AJun 4, 2021Anahuac University, Instituto de Seguridad y Servicios Sociales de los Trabajadores del Estado
NCT06385041N/AMay 12, 2021Lithuanian University of Health Sciences
NCT05456438N/AFeb 14, 2021Hitit University
NCT04554901N/ASep 1, 2020University of The West Indies
NCT04857554N/AJul 30, 2020Agricultural University of Athens
NCT04444388N/AJul 1, 2020Universidad Europea de Madrid
Showing 20 of 79 trials
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Organizations

Research & Development (83)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Mars, Inc.For profit6022006
University of California, DavisAcademic/Hospital6422007
University of ReadingAcademic/Hospital6612008
University of NottinghamAcademic/Hospital5512006
University of DuesseldorfAcademic/Hospital4322008
Harvard UniversityAcademic/Hospital3222009
NestleFor profit3312007
The Hershey CompanyFor profit3012012
Biotechnology and Biological Sciences Research CouncilAcademic/Hospital2012009
National Institute on Aging (NIA)Government2012016
Rovira i Virgili UniversityAcademic/Hospital2222005
University of HullAcademic/Hospital2112011
Agricultural University of AthensAcademic/Hospital1112020
Anahuac UniversityAcademic/Hospital1112021
Badalona Hospital Germans Trias i PujolAcademic/Hospital1012015
Boston UniversityAcademic/Hospital1012012
Cayetano Heredia UniversityAcademic/Hospital1112024
City University of New YorkAcademic/Hospital1112015
Clinica Universidad de NavarraAcademic/Hospital1112012
Columbia UniversityAcademic/Hospital1112015
83 organizations
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