betulinic acid
Betulinic acid is a naturally occurring pentacyclic triterpenoid which has antiretroviral, antimalarial, and anti-inflammatory properties, as well as a more recently discovered potential as an anticancer agent, by inhibition of topoisomerase. It is found in the bark of several species of plants, principally the white birch from which it gets its name, same as the bracket fungus Fomitopsis betulina, but also the ber tree, selfheal, the tropical carnivorous plants Triphyophyllum peltatum and Ancistrocladus heyneanus, Diospyros leucomelas, a member of the persimmon family, Tetracera boiviniana, the jambul, flowering quince, rosemary, and Pulsatilla chinensis. — Wikipedia
Clinical trial activity
2 trials · 3 clinical orgs · 0 marketing orgs
Earliest trial started Jan 1, 2006 (NCT00346502)
Timeline
2000s
- Jan 1, 2006
Earliest Phase 1 Sponsor(trial)
Indications
Mechanism of action
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
SMILES
C=C(C)[C@@H]1CC[C@]2(C(=O)O)CC[C@]3(C)[C@H](CC[C@@H]4[C@@]5(C)CC[C@H](O)C(C)(C)[C@@H]5CC[C@]43C)[C@@H]12- Mol. weight
- 456.71 g/mol
- Lipinski Ro5
- 1 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaBetulinic acid ↗
- ChEMBLCHEMBL269277 ↗
Also known as
- 3-epi-betulinic acid
- 3-hydroxylup-20(29)-en-28-oic acid
- als-357
- als-357
- beta-betulinic acid
- beta-betulinic acid
- betulic acid
- betulinic acid
- betulinic acid
- betulinic acid
- betulinic acid
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00701987 | Phase 1 | Jun 1, 2008 | Advanced Life Sciences, Northwestern University |
| NCT00346502 | Phase 1/Phase 2 (Phase 2) | Jan 1, 2006 | University of Illinois at Chicago |
Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Advanced Life Sciences | For profit | 1 | 1 | 1 | 2008 |
| Northwestern University | Academic/Hospital | 1 | 0 | 1 | 2008 |
| University of Illinois at Chicago | Academic/Hospital | 1 | 1 | 1 | 2006 |