cfi-400945
Small moleculeexperimental
Clinical trial activity
6 trials · 13 clinical orgs · 0 marketing orgs
Phase 1
3
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started Mar 1, 2014 (NCT01954316)
Timeline
Indications
Mechanism of action
- Serine/threonine-protein kinase PLK4INHIBITOR
PLK4 inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
COc1ccc2c(c1)[C@]1(C[C@H]1c1ccc3c(/C=C/c4ccc(CN5C[C@@H](C)O[C@@H](C)C5)cc4)n[nH]c3c1)C(=O)N2.O=C(O)/C=C/C(=O)O- Mol. weight
- 650.73 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL4297462 ↗
Also known as
- 2-(3-(4-((2,6-dimethylmorpholino)methyl)styryl)-1h-indazol-6-yl)-5'-methoxyspiro(cyclopropane-1,3'-indolin)-2'-one
- cfi-400945
- cfi-400945
- cfi-400945
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04730258 | Phase 1/Phase 2 (Phase 2) | Apr 16, 2021 | Treadwell Therapeutics, Inc, University of Texas at Houston |
| NCT04176848 | Phase 2 | Nov 30, 2019 | AstraZeneca, Canadian Cancer Trials Group, Queen's University, Belfast, University of Toronto |
| NCT03624543 | Phase 2 | Aug 30, 2018 | Canadian Cancer Trials Group, Stand Up To Cancer, University of Toronto |
| NCT03385655 | Phase 2 | Dec 12, 2017 | British Columbia Cancer Agency, Canadian Cancer Clinical Trials Network, Canadian Cancer Trials Group, Hamilton Health Sciences Corporation, University of Alberta, University of Ottawa |
| NCT03187288 | Phase 1 | Jul 24, 2017 | University of Toronto |
| NCT01954316 | Phase 1 | Mar 1, 2014 | California Institute for Regenerative Medicine, University of Toronto |
Showing 6 of 6 trials
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Organizations
Research & Development (13)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| University of Toronto | Academic/Hospital | 4 | 2 | 2 | 2014 |
| Canadian Cancer Trials Group | Academic/Hospital | 3 | 3 | 1 | 2017 |
| AstraZeneca | For profit | 1 | 0 | 1 | 2019 |
| British Columbia Cancer Agency | Academic/Hospital | 1 | 0 | 1 | 2017 |
| California Institute for Regenerative Medicine | Academic/Hospital | 1 | 0 | 1 | 2014 |
| Canadian Cancer Clinical Trials Network | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Hamilton Health Sciences Corporation | Academic/Hospital | 1 | 0 | 1 | 2017 |
| Queen's University, Belfast | Academic/Hospital | 1 | 0 | 1 | 2019 |
| Stand Up To Cancer | Academic/Hospital | 1 | 0 | 1 | 2018 |
| Treadwell Therapeutics, Inc | For profit | 1 | 1 | 1 | 2021 |
| University of Alberta | Academic/Hospital | 1 | 0 | 1 | 2017 |
| University of Ottawa | Academic/Hospital | 1 | 0 | 1 | 2017 |
| University of Texas at Houston | Academic/Hospital | 1 | 0 | 1 | 2021 |
13 organizations
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