2-hydroxyoleic acid

Small moleculeexperimental

Clinical trial activity

5 trials · 13 clinical orgs · 0 marketing orgs

Phase 1
3
Phase 2
4
Phase 3
0
Phase 4
0

Earliest trial started May 1, 2013 (NCT01792310)

Timeline

2010s

  1. Jan 1, 2013

    Earliest Phase 1 Sponsor(trial)

  2. Jan 1, 2019

    Earliest Phase 2 Sponsor(trial)

Indications

Mechanism of action

  • Cell membraneDISRUPTING AGENT

    Cell membrane disrupting agent

    Mechanism not fully elucidated. May inhibit lysophosphatidylcholine acyltransferase.

  • Unspecified targetUnclear

    unclear

Chemistry & pharmacology

Loading structure…

SMILES

CCCCCCCC\C=C/CCCCCCC(O)C(O)=O
Mol. weight
298.4608 g/mol
Lipinski Ro5
1 violation(s)
Rule of 3
No
Chirality
Racemic Mixture
Inorganic
No
Polymer
No

Oral

No

Parenteral

No

Topical

No

Sources

Also known as

  • 2-hydroxyoleic acid
  • 2-hydroxyoleic acid
  • 2-hydroxyoleic acid
  • 2-ohoa compound

Clinical trials

NCT IDPhaseStart dateSponsor(s)
NCT04299191Phase 1/Phase 2 (Phase 2)Mar 31, 2020Hackensack University Medical Center, Harvard University, Laminar Pharmaceuticals
NCT04148573Phase 2Oct 1, 2019Hospital Nacional de Paraplejicos, Neurofix S.L.
NCT04250922Phase 2Apr 1, 2019Lipodom Therapeutics, Lipopharma Therapeutics SL, Newcastle University, Specialized Medical Services, Oncology BV, Theradis pharma
NCT03867123Phase 1Dec 4, 2018Lipopharma Therapeutics SL
NCT01792310Phase 1/Phase 2 (Phase 2)May 1, 2013Lipopharma Therapeutics SL, Newcastle University, Royal Marsden Hospital NHS Trust, Specialized Medical Services, Oncology BV, Universidad Autonoma de Barcelona, University of London
Showing 5 of 5 trials
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Organizations

Research & Development (13)

OrganizationOrg typeTrialsAs lead sponsorPhasesEarliest year
Lipopharma Therapeutics SLFor profit3322013
Newcastle UniversityAcademic/Hospital2012013
Specialized Medical Services, Oncology BVAcademic/Hospital2012013
Hackensack University Medical CenterAcademic/Hospital1012020
Harvard UniversityAcademic/Hospital1012020
Hospital Nacional de ParaplejicosAcademic/Hospital1012019
Laminar PharmaceuticalsFor profit1112020
Lipodom TherapeuticsFor profit1012019
Neurofix S.L.For profit1112019
Royal Marsden Hospital NHS TrustAcademic/Hospital1012013
Theradis pharmaFor profit1012019
Universidad Autonoma de BarcelonaAcademic/Hospital1012013
University of LondonAcademic/Hospital1012013
13 organizations
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