cep-1347
Clinical trial activity
1 trials · 3 clinical orgs · 0 marketing orgs
Earliest trial started Mar 1, 2002 (NCT00040404)
Timeline
2000s
- Jan 1, 2002
Earliest Phase 2 Sponsor(trial)
Indications
Studied for
Mechanism of action
MAP3K10 inhibitor
CEP-1347 inhibits c-Jun N-terminal kinase signaling pathway by inhibition of mixed lineage kinases (MLKs), upstreams and known activators of JNK signaling.
MAP3K13 inhibitor
CEP-1347 inhibits c-Jun N-terminal kinase signaling pathway by inhibition of mixed lineage kinases (MLKs), upstreams and known activators of JNK signaling.
MAP3K11 inhibitor
CEP-1347 inhibits c-Jun N-terminal kinase signaling pathway by inhibition of mixed lineage kinases (MLKs), upstreams and known activators of JNK signaling.
MAP3K9 inhibitor
CEP-1347 inhibits c-Jun N-terminal kinase signaling pathway by inhibition of mixed lineage kinases (MLKs), upstreams and known activators of JNK signaling.
MAP3K12 inhibitor
CEP-1347 inhibits c-Jun N-terminal kinase signaling pathway by inhibition of mixed lineage kinases (MLKs), upstreams and known activators of JNK signaling.
Chemistry & pharmacology
SMILES
CCSCc1ccc2c(c1)c1c3c(c4c5cc(CSCC)ccc5n5c4c1n2[C@H]1C[C@](O)(C(=O)OC)[C@]5(C)O1)CNC3=O- Mol. weight
- 615.78 g/mol
- Lipinski Ro5
- 2 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL290352 ↗
Also known as
- 3,9-bis((ethylthio)methyl)-k-252a
- 3,9-bis(etsm)-k-252a
- cep1347
- cep1347
- cep1347
- cep 1347
- cep-1347
- cep-1347
- cep-1347
- cep-1347
- cep-1347
- kt-1575
- kt-1575
- kt7515
- kt 7515
- kt-7515
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT00040404 | Phase 2/Phase 3 (Phase 3) | Mar 1, 2002 | Cephalon, Lundbeck, The Parkinson Study Group |
Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Cephalon | For profit | 1 | 1 | 1 | 2002 |
| Lundbeck | For profit | 1 | 0 | 1 | 2002 |
| The Parkinson Study Group | Academic/Hospital | 1 | 0 | 1 | 2002 |