chimeric natriuretic peptide
Peptideexperimental
Cenderitide is a natriuretic peptide developed by the Mayo Clinic as a potential treatment for heart failure. Cenderitide is created by the fusion of the 15 amino acid C-terminus of the snake venom dendroaspis natriuretic peptide (DNP) with the full C-type natriuretic peptide (CNP) structure. This peptide chimera is a dual activator of the natriuretic peptide receptors NPR-A and NPR-B and therefore exhibits the natriuretic and diuretic properties of DNP, as well as the antiproliferative and antifibrotic properties of CNP. — Wikipedia
Clinical trial activity
8 trials · 5 clinical orgs · 0 marketing orgs
Phase 1
6
Phase 2
2
Phase 3
0
Phase 4
0
Earliest trial started Jan 1, 2007 (NCT00482937)
Timeline
Indications
Mechanism of action
- Atrial natriuretic factorSupplementation
NPPA supplementation
Chemistry & pharmacology
- Multi-specific
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaCenderitide ↗
- WikipediaCD-NP ↗
Also known as
- chimeric natriuretic peptide
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT01407900 | Phase 1 | Jan 1, 2014 | Mayo Clinic, National Institutes of Health (NIH) |
| NCT02071602 | Phase 1 | Oct 1, 2013 | Mayo Clinic |
| NCT01750905 | Phase 1 | Apr 1, 2013 | Mayo Clinic |
| NCT00839007 | Phase 2 | Jun 1, 2009 | Nile Therapeutics |
| NCT00699712 | Phase 2 | Jun 1, 2008 | Momentum Research, Inc., Nile Therapeutics |
| NCT00620308 | Phase 1 | Jun 1, 2008 | Mayo Clinic |
| NCT00557661 | Phase 1 | Nov 1, 2007 | Hennepin Healthcare, Nile Therapeutics |
| NCT00482937 | Phase 1 | Jan 1, 2007 | Nile Therapeutics |
Showing 8 of 8 trials
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Organizations
Research & Development (5)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Mayo Clinic | Academic/Hospital | 4 | 4 | 1 | 2008 |
| Nile Therapeutics | For profit | 4 | 4 | 2 | 2007 |
| Hennepin Healthcare | Academic/Hospital | 1 | 0 | 1 | 2007 |
| Momentum Research, Inc. | For profit | 1 | 0 | 1 | 2008 |
| National Institutes of Health (NIH) | Government | 1 | 0 | 1 | 2014 |
5 organizations
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