cavosonstat
Small moleculeexperimental
Clinical trial activity
9 trials · 7 clinical orgs · 0 marketing orgs
Phase 1
5
Phase 2
4
Phase 3
0
Phase 4
0
Earliest trial started Feb 1, 2014 (NCT02013388)
Timeline
Indications
Mechanism of action
- Alcohol dehydrogenase class IIIINHIBITOR
Alcohol dehydrogenase class III inhibitor
Chemistry & pharmacology
Loading structure…
SMILES
O=C(O)c1ccc(-c2ccc3cc(O)ccc3n2)c(Cl)c1- Mol. weight
- 299.71 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- ChEMBLCHEMBL3989910 ↗
Also known as
- cavosonstat
- cavosonstat
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04600778 | Phase 2 | Feb 3, 2021 | N30 Pharmaceuticals |
| NCT04129931 | Phase 2 | Nov 30, 2019 | National Heart, Lung, and Blood Institute (NHLBI), University of North Carolina at Chapel Hill |
| NCT02934139 | Phase 1 | Oct 1, 2016 | Davita Clinical Research, Nivalis Therapeutics, Inc. |
| NCT02724527 | Phase 2 | Apr 1, 2016 | Case Western Reserve University, Nivalis Therapeutics, Inc. |
| NCT02589236 | Phase 2 | Nov 1, 2015 | Medidata Solutions, Nivalis Therapeutics, Inc., University of North Carolina at Chapel Hill |
| NCT02500667 | Phase 1 | Jun 1, 2015 | Davita Clinical Research, Nivalis Therapeutics, Inc. |
| NCT02275936 | Phase 1 | Feb 1, 2015 | Nivalis Therapeutics, Inc., University of North Carolina at Chapel Hill |
| NCT02227888 | Phase 1 | Oct 1, 2014 | Nivalis Therapeutics, Inc. |
| NCT02013388 | Phase 1 | Feb 1, 2014 | Davita Clinical Research, Nivalis Therapeutics, Inc. |
Showing 9 of 9 trials
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Organizations
Research & Development (7)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Nivalis Therapeutics, Inc. | For profit | 7 | 7 | 2 | 2014 |
| Davita Clinical Research | For profit | 3 | 0 | 1 | 2014 |
| University of North Carolina at Chapel Hill | Academic/Hospital | 3 | 1 | 2 | 2015 |
| Case Western Reserve University | Academic/Hospital | 1 | 0 | 1 | 2016 |
| Medidata Solutions | For profit | 1 | 0 | 1 | 2015 |
| N30 Pharmaceuticals | For profit | 1 | 1 | 1 | 2021 |
| National Heart, Lung, and Blood Institute (NHLBI) | Government | 1 | 0 | 1 | 2019 |
7 organizations
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