caffeic acid
Caffeic acid is an organic compound with the formula (HO)2C6H3CH=CHCO2H. It is a polyphenol with a key role in scavenging reactive oxygen species (ROS) generated in energy metabolism. Caffeic acid is also one major polyphenol responsible for maintaining normal levels of nitric oxide (NO) within cells. Caffeic acid is a yellow, solid chemical compound that is structually classified as a hydroxycinnamic acid, and the molecule consists of both phenolic and acrylic functional groups. Caffeic acid is found in all plants as an intermediate in the biosynthesis of lignin, a naturally occurring complex carbohydrate representing the principal components of biomass and its residues. It is chemically unrelated to caffeine; instead, the shared name is related to its presence in coffee. — Wikipedia
Clinical trial activity
4 trials · 8 clinical orgs · 0 marketing orgs
Earliest trial started Sep 1, 2012 (NCT02351622)
Timeline
2010s
- Jan 1, 2012
Earliest Phase 3 Sponsor(trial)
Indications
Approved for
Mechanism of action
- Unspecified targetAntioxidant
antioxidant
Chemistry & pharmacology
SMILES
O=C(O)/C=C/c1ccc(O)c(O)c1- Mol. weight
- 180.16 g/mol
- Lipinski Ro5
- Pass
- Rule of 3
- No
- Chirality
- Achiral Molecule
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaCaffeic acid ↗
- ChEMBLCHEMBL145 ↗
Also known as
- 3,4-dihydroxycinnamic acid
- caffeic acid
- caffeic acid
- caffeic acid
- caffeic acid, (e)-isomer
- caffeic acid, monosodium salt
- caffeic acid, (z)-isomer
- sodium caffeate
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04648917 | Phase 3 | May 1, 2019 | Henan Medical University |
| NCT03070262 | Phase 3 | Jan 1, 2017 | Anyang Regional Hospital, Henan Medical University, People's Liberation Army of China |
| NCT02556814 | Phase 4 | Sep 1, 2015 | Shandong University |
| NCT02351622 | Phase 3 | Sep 1, 2012 | Anhui Medical University, Qingdao University, Shandong Province Qianfoshan Hospital, Shandong Provincial Hospital, Shandong University |
Organizations
Research & Development (8)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Henan Medical University | Academic/Hospital | 2 | 2 | 1 | 2017 |
| Shandong University | Academic/Hospital | 2 | 2 | 2 | 2012 |
| Anhui Medical University | Academic/Hospital | 1 | 0 | 1 | 2012 |
| Anyang Regional Hospital | Academic/Hospital | 1 | 0 | 1 | 2017 |
| People's Liberation Army of China | Government | 1 | 0 | 1 | 2017 |
| Qingdao University | Academic/Hospital | 1 | 0 | 1 | 2012 |
| Shandong Province Qianfoshan Hospital | Academic/Hospital | 1 | 0 | 1 | 2012 |
| Shandong Provincial Hospital | Academic/Hospital | 1 | 0 | 1 | 2012 |