brilacidin
Brilacidin, an investigational new drug, is a polymer-based antibiotic currently in human clinical trials, and represents a new class of antibiotics called host defense protein mimetics, or HDP-mimetics, which are non-peptide synthetic small molecules modeled after host defense peptides (HDPs). HDPs, also called antimicrobial peptides, some of which are defensins, are part of the innate immune response and are common to most higher forms of life. As brilacidin is modeled after a defensin, it is also called a defensin mimetic. — Wikipedia
Clinical trial activity
5 trials · 3 clinical orgs · 0 marketing orgs
Earliest trial started Oct 1, 2010 (NCT01211470)
Timeline
Indications
Mechanism of action
- MembraneDISRUPTING AGENT
Membrane disrupting agent
Possibly also binds to heparan sulfate proteoglycans on the host cell surface, blocking viral attachment (https://www.biorxiv.org/content/10.1101/2021.11.04.467344v1).
- Unspecified targetUnclear
unclear
Chemistry & pharmacology
SMILES
N=C(N)NCCCCC(=O)Nc1cc(C(F)(F)F)cc(NC(=O)c2cc(C(=O)Nc3cc(C(F)(F)F)cc(NC(=O)CCCCNC(=N)N)c3O[C@@H]3CCNC3)ncn2)c1O[C@@H]1CCNC1- Mol. weight
- 936.92 g/mol
- Lipinski Ro5
- 3 violation(s)
- Rule of 3
- No
- Chirality
- Single Stereoisomer
- Inorganic
- No
- Polymer
- No
Oral
No
Parenteral
No
Topical
No
Sources
- WikipediaBrilacidin ↗
- ChEMBLCHEMBL2219413 ↗
Also known as
- brilacidin
- brilacidin
- brilacidin
- brilacidin
- brilacidin
- pmx30063
- pmx-30063
- pmx-30063
- pmx-30063
Clinical trials
| NCT ID | Phase | Start date | Sponsor(s) |
|---|---|---|---|
| NCT04784897 | Phase 2 | Feb 22, 2021 | Innovation Pharmaceuticals |
| NCT04240223 | Phase 1 | Jan 6, 2020 | BDD Pharma Ltd, Innovation Pharmaceuticals |
| NCT02324335 | Phase 2 | May 1, 2015 | Innovation Pharmaceuticals |
| NCT02052388 | Phase 2 | Feb 1, 2014 | Innovation Pharmaceuticals |
| NCT01211470 | Phase 2 | Oct 1, 2010 | PolyMedix, Inc. |
Organizations
Research & Development (3)
| Organization | Org type | Trials | As lead sponsor | Phases | Earliest year |
|---|---|---|---|---|---|
| Innovation Pharmaceuticals | For profit | 4 | 4 | 2 | 2014 |
| BDD Pharma Ltd | For profit | 1 | 0 | 1 | 2020 |
| PolyMedix, Inc. | For profit | 1 | 1 | 1 | 2010 |